Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 96217..96730 Replicon chromosome
Accession NZ_CP094822
Organism Mammaliicoccus sciuri strain IVB6223

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA96_RS00425 Protein ID WP_262642262.1
Coordinates 96464..96730 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA96_RS00420 Protein ID WP_262642261.1
Coordinates 96217..96471 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA96_RS00395 (MUA96_00395) 91667..91984 + 318 WP_037589651.1 metalloregulator ArsR/SmtB family transcription factor -
MUA96_RS00400 (MUA96_00400) 92063..92986 + 924 WP_262642257.1 NAD-dependent epimerase/dehydratase family protein -
MUA96_RS00405 (MUA96_00405) 92988..93683 + 696 WP_262642258.1 type 1 glutamine amidotransferase domain-containing protein -
MUA96_RS00410 (MUA96_00410) 94302..95186 - 885 WP_262642259.1 SDR family NAD(P)-dependent oxidoreductase -
MUA96_RS00415 (MUA96_00415) 95202..95774 - 573 WP_262642260.1 TetR/AcrR family transcriptional regulator -
MUA96_RS00420 (MUA96_00420) 96217..96471 + 255 WP_262642261.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MUA96_RS00425 (MUA96_00425) 96464..96730 + 267 WP_262642262.1 Txe/YoeB family addiction module toxin Toxin
MUA96_RS00430 (MUA96_00430) 96823..97053 + 231 WP_262642263.1 DUF6290 family protein -
MUA96_RS00435 (MUA96_00435) 97118..98002 - 885 WP_262642264.1 ABC transporter permease subunit -
MUA96_RS00440 (MUA96_00440) 97999..98433 - 435 WP_262642265.1 ABC transporter permease subunit -
MUA96_RS00445 (MUA96_00445) 98463..98852 - 390 WP_262642266.1 hypothetical protein -
MUA96_RS00450 (MUA96_00450) 99021..99494 - 474 WP_262642267.1 GNAT family N-acetyltransferase -
MUA96_RS00455 (MUA96_00455) 99645..100004 - 360 WP_262642268.1 hypothetical protein -
MUA96_RS00460 (MUA96_00460) 100052..100270 - 219 WP_262642269.1 phosphoglycerate mutase family protein -
MUA96_RS00465 (MUA96_00465) 100406..101290 - 885 WP_262642270.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10571.20 Da        Isoelectric Point: 9.6417

>T240617 WP_262642262.1 NZ_CP094822:96464-96730 [Mammaliicoccus sciuri]
MSKRNITFTPTAFEDYEYWLEQDKKLLKKINRLIKSIQRDGQLEGEGKPEPLKGNLQGYCSRRINHEHRLVYMVKENHVI
IIGCRYQY

Download         Length: 267 bp

>T240617 NZ_LT601384:1374519-1375841 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9562.45 Da        Isoelectric Point: 4.1353

>AT240617 WP_262642261.1 NZ_CP094822:96217-96471 [Mammaliicoccus sciuri]
MTVISYSNARKNFRKLIDKVNNDSDTVTITTNESNDVLMGEDDYNSIMETLYLQQSPANAKHLAKSIEEAERNNTVEVDI
DSYE

Download         Length: 255 bp

>AT240617 NZ_LT601384:1374253-1374519 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References