Detailed information of TA system TA240605

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 96053..96566
• Replicon: chromosome
• Accession: NZ_CP094819
• Organism: Mammaliicoccus sciuri strain IVB6228

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUA42_RS00425
• Protein ID: WP_262642262.1
• Coordinates: 96300..96566 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MUA42_RS00420
• Protein ID: WP_262642261.1
• Coordinates: 96053..96307 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA42_RS00395 (MUA42_00395)	91503..91820	+	318	WP_037589651.1	metalloregulator ArsR/SmtB family transcription factor	-
MUA42_RS00400 (MUA42_00400)	91899..92822	+	924	WP_262642257.1	NAD-dependent epimerase/dehydratase family protein	-
MUA42_RS00405 (MUA42_00405)	92824..93519	+	696	WP_262642258.1	type 1 glutamine amidotransferase domain-containing protein	-
MUA42_RS00410 (MUA42_00410)	94138..95022	-	885	WP_262642259.1	SDR family NAD(P)-dependent oxidoreductase	-
MUA42_RS00415 (MUA42_00415)	95038..95610	-	573	WP_262642260.1	TetR/AcrR family transcriptional regulator	-
MUA42_RS00420 (MUA42_00420)	96053..96307	+	255	WP_262642261.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MUA42_RS00425 (MUA42_00425)	96300..96566	+	267	WP_262642262.1	Txe/YoeB family addiction module toxin	Toxin
MUA42_RS00430 (MUA42_00430)	96659..96889	+	231	WP_262642263.1	DUF6290 family protein	-
MUA42_RS00435 (MUA42_00435)	96954..97838	-	885	WP_262642264.1	ABC transporter permease subunit	-
MUA42_RS00440 (MUA42_00440)	97835..98302	-	468	WP_262657973.1	ABC transporter permease subunit	-
MUA42_RS00445 (MUA42_00445)	98299..98688	-	390	WP_262642266.1	hypothetical protein	-
MUA42_RS00450 (MUA42_00450)	98857..99330	-	474	WP_262642267.1	GNAT family N-acetyltransferase	-
MUA42_RS00455 (MUA42_00455)	99481..99840	-	360	WP_262642268.1	hypothetical protein	-
MUA42_RS00460 (MUA42_00460)	99888..100106	-	219	WP_262642269.1	phosphoglycerate mutase family protein	-
MUA42_RS00465 (MUA42_00465)	100242..101126	-	885	WP_262642270.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10571.20 Da
• Isoelectric Point: 9.6417

>T240605 WP_262642262.1 NZ_CP094819:96300-96566 [Mammaliicoccus sciuri]
MSKRNITFTPTAFEDYEYWLEQDKKLLKKINRLIKSIQRDGQLEGEGKPEPLKGNLQGYCSRRINHEHRLVYMVKENHVI
IIGCRYQY

Nucleotide

• Length: 267 bp

>T240605 NZ_LT598688:c2117518-2117267 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9562.45 Da
• Isoelectric Point: 4.1353

>AT240605 WP_262642261.1 NZ_CP094819:96053-96307 [Mammaliicoccus sciuri]
MTVISYSNARKNFRKLIDKVNNDSDTVTITTNESNDVLMGEDDYNSIMETLYLQQSPANAKHLAKSIEEAERNNTVEVDI
DSYE

Nucleotide

• Length: 255 bp

>AT240605 NZ_LT598688:c2117277-2117095 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA