Detailed information of TA system TA240578

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 344145..344304
• Replicon: chromosome
• Accession: NZ_CP094812
• Organism: Staphylococcus agnetis strain IVB6186

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: MUA43_RS01495
• Protein ID: WP_107365594.1
• Coordinates: 344145..344246 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	344271..344304 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA43_RS01475 (MUA43_01470)	339971..340411	+	441	WP_060551890.1	antibiotic biosynthesis monooxygenase family protein	-
MUA43_RS01480 (MUA43_01475)	340632..342116	-	1485	WP_262608665.1	HAMP domain-containing sensor histidine kinase	-
MUA43_RS01485 (MUA43_01480)	342109..342786	-	678	WP_037565806.1	response regulator transcription factor	-
MUA43_RS01490 (MUA43_01485)	343000..344010	+	1011	WP_262608666.1	HoxN/HupN/NixA family nickel/cobalt transporter	-
MUA43_RS01495 (MUA43_01490)	344145..344246	+	102	WP_107365594.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	344271..344304	-	34	-	-	Antitoxin
MUA43_RS01500 (MUA43_01495)	344415..344687	-	273	WP_103346255.1	DUF2316 family protein	-
MUA43_RS01505 (MUA43_01500)	344949..345359	+	411	WP_085622846.1	hypothetical protein	-
MUA43_RS01510 (MUA43_01505)	345477..346091	+	615	WP_262608667.1	DedA family protein	-
MUA43_RS01515 (MUA43_01510)	346164..346814	-	651	WP_262608668.1	zinc ribbon domain-containing protein	-
MUA43_RS01520 (MUA43_01515)	347033..348472	+	1440	WP_262608669.1	alkaline phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3789.56 Da
• Isoelectric Point: 10.7732

>T240578 WP_107365594.1 NZ_CP094812:344145-344246 [Staphylococcus agnetis]
MLDILVHITTTIISGCIVTLFAHWLRTRGNKHK

Nucleotide

• Length: 102 bp

>T240578 NZ_LT594504:c2482914-2481592 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Nucleotide

• Length: 34 bp

>AT240578 NZ_CP094812:c344304-344271 [Staphylococcus agnetis]
CACCAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Antitoxin