Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 11975..12498 Replicon plasmid unnamed2
Accession NZ_CP094805
Organism Staphylococcus arlettae strain IVB6235

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1E5TS43
Locus tag MUA37_RS13240 Protein ID WP_069816802.1
Coordinates 11975..12241 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1E5TS49
Locus tag MUA37_RS13245 Protein ID WP_069816800.1
Coordinates 12241..12498 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA37_RS13215 (MUA37_13190) 7650..8030 - 381 WP_262624970.1 MobC family plasmid mobilization relaxosome protein -
MUA37_RS13220 (MUA37_13195) 8423..8860 + 438 WP_262624971.1 hypothetical protein -
MUA37_RS13225 (MUA37_13200) 8887..9699 + 813 WP_071665032.1 hypothetical protein -
MUA37_RS13230 (MUA37_13205) 9760..11100 - 1341 WP_262624972.1 helix-turn-helix transcriptional regulator -
MUA37_RS13235 (MUA37_13210) 11234..11911 + 678 WP_262624973.1 hypothetical protein -
MUA37_RS13240 (MUA37_13215) 11975..12241 - 267 WP_069816802.1 Txe/YoeB family addiction module toxin Toxin
MUA37_RS13245 (MUA37_13220) 12241..12498 - 258 WP_069816800.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA37_RS13250 (MUA37_13225) 12703..12795 + 93 WP_107513893.1 type I toxin-antitoxin system Fst family toxin -
MUA37_RS13255 (MUA37_13230) 12983..13375 - 393 Protein_16 IS6 family transposase -
MUA37_RS13260 (MUA37_13235) 13546..14199 - 654 Protein_17 ABC transporter permease -
MUA37_RS13265 (MUA37_13240) 14418..15011 + 594 WP_262624598.1 recombinase family protein -
MUA37_RS13270 (MUA37_13245) 14983..16425 + 1443 WP_262624599.1 Mu transposase C-terminal domain-containing protein -
MUA37_RS13275 (MUA37_13250) 16418..17233 + 816 WP_262624600.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..28347 28347
- flank IS/Tn - - 12932..13375 443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(23-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10438.86 Da        Isoelectric Point: 10.0455

>T240559 WP_069816802.1 NZ_CP094805:c12241-11975 [Staphylococcus arlettae]
MGNYNVSIKNSAKSDLKKIKQSQLKTQFLKIVETLKEDPYFPNQSFEKLQPKHLGRYSRRINHQHRVVYTVDEDSKEVLI
TSAWSHYE

Download         Length: 267 bp

>T240559 NZ_LT592156:2355-2633 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9749.68 Da        Isoelectric Point: 4.1730

>AT240559 WP_069816800.1 NZ_CP094805:c12498-12241 [Staphylococcus arlettae]
MNIKTPTNARKEFYELLKQVNDSHEPVIISGSKSENNAVIIGQKDWNSIQETLYLESTGTMDKVRERENDSSGFTDIDDL
DWDNI

Download         Length: 258 bp

>AT240559 NZ_LT592156:2170-2355 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E5TS43

Antitoxin

Source ID Structure
AlphaFold DB A0A1E5TS49

References