240556

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2573723..2574246 Replicon chromosome
Accession NZ_CP094801
Organism Staphylococcus aureus strain IVB6155

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag MUA25_RS13005 Protein ID WP_000074047.1
Coordinates 2573723..2573989 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag MUA25_RS13010 Protein ID WP_000587617.1
Coordinates 2573989..2574246 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA25_RS12985 (MUA25_12980) 2568933..2570120 - 1188 WP_000026190.1 MFS transporter -
MUA25_RS12990 (MUA25_12985) 2570514..2571290 - 777 WP_252592260.1 iron export ABC transporter permease subunit FetB -
MUA25_RS12995 (MUA25_12990) 2571283..2571945 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
MUA25_RS13000 (MUA25_12995) 2572291..2573367 - 1077 WP_001076679.1 M42 family metallopeptidase -
MUA25_RS13005 (MUA25_13000) 2573723..2573989 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
MUA25_RS13010 (MUA25_13005) 2573989..2574246 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA25_RS13015 (MUA25_13010) 2574606..2575061 + 456 WP_000732090.1 YehR family lipoprotein -
MUA25_RS13020 (MUA25_13015) 2575229..2576806 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
MUA25_RS13025 (MUA25_13020) 2577002..2577751 + 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA25_RS13030 (MUA25_13025) 2577975..2579168 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T240556 WP_000074047.1 NZ_CP094801:c2573989-2573723 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240556 NZ_LT592154:2355-2633 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT240556 WP_000587617.1 NZ_CP094801:c2574246-2573989 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240556 NZ_LT592154:2170-2355 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References