Detailed information of TA system TA240554

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2542407..2542591
• Replicon: chromosome
• Accession: NZ_CP094801
• Organism: Staphylococcus aureus strain IVB6155

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA25_RS12865
• Protein ID: WP_000482647.1
• Coordinates: 2542484..2542591 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2542407..2542467 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA25_RS12850 (MUA25_12845)	2537917..2538084	-	168	Protein_2488	hypothetical protein	-
MUA25_RS12855 (MUA25_12850)	2538315..2540048	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
MUA25_RS12860 (MUA25_12855)	2540073..2541836	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	2542407..2542467	+	61	-	-	Antitoxin
MUA25_RS12865 (MUA25_12860)	2542484..2542591	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA25_RS12870 (MUA25_12865)	2542725..2543111	-	387	WP_000779351.1	flippase GtxA	-
MUA25_RS12875 (MUA25_12870)	2543379..2544521	+	1143	WP_001176855.1	glycerate kinase	-
MUA25_RS12880 (MUA25_12875)	2544581..2545240	+	660	WP_000831298.1	membrane protein	-
MUA25_RS12885 (MUA25_12880)	2545422..2546633	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
MUA25_RS12890 (MUA25_12885)	2546756..2547229	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240554 WP_000482647.1 NZ_CP094801:c2542591-2542484 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240554 NZ_LT592153:723596-724015 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240554 NZ_CP094801:2542407-2542467 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin