240553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2517106..2517623 Replicon chromosome
Accession NZ_CP094801
Organism Staphylococcus aureus strain IVB6155

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag MUA25_RS12730 Protein ID WP_000251928.1
Coordinates 2517106..2517372 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag MUA25_RS12735 Protein ID WP_000584497.1
Coordinates 2517372..2517623 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA25_RS12705 (MUA25_12700) 2512313..2512849 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
MUA25_RS12710 (MUA25_12705) 2513317..2514141 - 825 WP_262612340.1 formate/nitrite transporter family protein -
MUA25_RS12715 (MUA25_12710) 2514344..2514526 - 183 WP_000079140.1 hypothetical protein -
MUA25_RS12720 (MUA25_12715) 2514613..2515080 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA25_RS12725 (MUA25_12720) 2515266..2516813 - 1548 WP_045179540.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA25_RS12730 (MUA25_12725) 2517106..2517372 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
MUA25_RS12735 (MUA25_12730) 2517372..2517623 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA25_RS12740 (MUA25_12735) 2517787..2517887 - 101 Protein_2466 hypothetical protein -
MUA25_RS12745 (MUA25_12740) 2517894..2518493 - 600 WP_000162804.1 DsbA family protein -
MUA25_RS12750 (MUA25_12745) 2518512..2518874 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA25_RS12755 (MUA25_12750) 2519129..2520379 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
MUA25_RS12760 (MUA25_12755) 2520476..2521207 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
MUA25_RS12765 (MUA25_12760) 2521204..2521923 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T240553 WP_000251928.1 NZ_CP094801:c2517372-2517106 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240553 NZ_LT592152:2355-2633 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT240553 WP_000584497.1 NZ_CP094801:c2517623-2517372 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT240553 NZ_LT592152:2170-2355 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References