Detailed information of TA system TA240548

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1922920..1923100
• Replicon: chromosome
• Accession: NZ_CP094801
• Organism: Staphylococcus aureus strain IVB6155

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA25_RS09415
• Protein ID: WP_001801861.1
• Coordinates: 1922920..1923015 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1923043..1923100 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA25_RS09385 (MUA25_09380)	1918064..1918690	+	627	WP_000669038.1	hypothetical protein	-
MUA25_RS09390 (MUA25_09385)	1918731..1919075	+	345	WP_000627550.1	DUF3969 family protein	-
MUA25_RS09395 (MUA25_09390)	1919173..1919745	+	573	WP_000414222.1	hypothetical protein	-
MUA25_RS09400 (MUA25_09395)	1919894..1921261	-	1368	WP_001093574.1	FRG domain-containing protein	-
MUA25_RS09405 (MUA25_09400)	1921261..1921830	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
MUA25_RS09410 (MUA25_09405)	1922023..1922469	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
MUA25_RS09415 (MUA25_09410)	1922920..1923015	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1923043..1923100	-	58	-	-	Antitoxin
MUA25_RS09420 (MUA25_09415)	1923138..1923239	+	102	WP_001791232.1	hypothetical protein	-
MUA25_RS09425 (MUA25_09420)	1923414..1923857	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
MUA25_RS09430 (MUA25_09425)	1923857..1924300	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
MUA25_RS09435 (MUA25_09430)	1924300..1924742	-	443	Protein_1857	DUF1433 domain-containing protein	-
MUA25_RS09440 (MUA25_09435)	1925267..1927687	+	2421	WP_045179297.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240548 WP_001801861.1 NZ_CP094801:1922920-1923015 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240548 NZ_LT592146:657491-657910 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240548 NZ_CP094801:c1923100-1923043 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin