Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1592516..1593095 | Replicon | chromosome |
| Accession | NZ_CP094801 | ||
| Organism | Staphylococcus aureus strain IVB6155 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | MUA25_RS07785 | Protein ID | WP_001025401.1 |
| Coordinates | 1592850..1593095 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1592516..1592881 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA25_RS07705 (MUA25_07700) | 1587683..1588111 | - | 429 | WP_045178958.1 | single-stranded DNA-binding protein | - |
| MUA25_RS07710 (MUA25_07705) | 1588111..1588749 | - | 639 | WP_001043063.1 | ERF family protein | - |
| MUA25_RS07715 (MUA25_07710) | 1588749..1589228 | - | 480 | WP_031824890.1 | siphovirus Gp157 family protein | - |
| MUA25_RS07720 (MUA25_07715) | 1589243..1589503 | - | 261 | WP_262612275.1 | DUF1108 family protein | - |
| MUA25_RS07725 (MUA25_07720) | 1589595..1589915 | - | 321 | WP_000219664.1 | hypothetical protein | - |
| MUA25_RS07730 (MUA25_07725) | 1589916..1590083 | - | 168 | WP_045178556.1 | DUF1270 domain-containing protein | - |
| MUA25_RS07735 (MUA25_07730) | 1590067..1590204 | - | 138 | WP_001568566.1 | hypothetical protein | - |
| MUA25_RS07740 (MUA25_07735) | 1590263..1590475 | + | 213 | WP_000461464.1 | hypothetical protein | - |
| MUA25_RS07745 (MUA25_07740) | 1590490..1590567 | - | 78 | Protein_1520 | hypothetical protein | - |
| MUA25_RS07750 (MUA25_07745) | 1590580..1590843 | - | 264 | WP_001124185.1 | helix-turn-helix domain-containing protein | - |
| MUA25_RS07755 (MUA25_07750) | 1590993..1591091 | - | 99 | Protein_1522 | hypothetical protein | - |
| MUA25_RS07760 (MUA25_07755) | 1591088..1591414 | - | 327 | WP_001025595.1 | hypothetical protein | - |
| MUA25_RS07765 (MUA25_07760) | 1591741..1591980 | - | 240 | WP_001294156.1 | hypothetical protein | - |
| MUA25_RS07770 (MUA25_07765) | 1592040..1592267 | + | 228 | WP_000801108.1 | hypothetical protein | - |
| MUA25_RS07775 (MUA25_07770) | 1592269..1592460 | - | 192 | WP_000389906.1 | hypothetical protein | - |
| MUA25_RS07780 (MUA25_07775) | 1592516..1592881 | + | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| MUA25_RS07785 (MUA25_07780) | 1592850..1593095 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| MUA25_RS07790 (MUA25_07785) | 1593124..1593900 | - | 777 | WP_072519170.1 | Rha family transcriptional regulator | - |
| MUA25_RS07795 (MUA25_07790) | 1593914..1594150 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| MUA25_RS07800 (MUA25_07795) | 1594302..1594616 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | - |
| MUA25_RS07805 (MUA25_07800) | 1594629..1595090 | + | 462 | WP_045179173.1 | toxin | - |
| MUA25_RS07810 (MUA25_07805) | 1595271..1595462 | + | 192 | WP_252559444.1 | hypothetical protein | - |
| MUA25_RS07815 (MUA25_07810) | 1595459..1596037 | - | 579 | WP_252559441.1 | hypothetical protein | - |
| MUA25_RS07820 (MUA25_07815) | 1596163..1597368 | + | 1206 | WP_262518205.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sak / sea / gnd | 1554973..1624339 | 69366 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T240544 WP_001025401.1 NZ_CP094801:c1593095-1592850 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T240544 NZ_LT591910:728184-728603 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA
Antitoxin
Download Length: 366 bp
>AT240544 NZ_CP094801:1592516-1592881 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
