Detailed information of TA system TA240541

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1557792..1558083
• Replicon: chromosome
• Accession: NZ_CP094801
• Organism: Staphylococcus aureus strain IVB6155

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MUA25_RS07480
• Protein ID: WP_252559492.1
• Coordinates: 1557907..1558083 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1557792..1557848 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA25_RS07440 (MUA25_07435)	1552867..1553013	-	147	WP_001033756.1	hypothetical protein	-
MUA25_RS07445 (MUA25_07440)	1553006..1553920	-	915	WP_000476887.1	DUF1672 domain-containing protein	-
MUA25_RS07450 (MUA25_07445)	1553978..1554883	-	906	WP_000913238.1	DUF1672 domain-containing protein	-
MUA25_RS07455 (MUA25_07450)	1554973..1555188	-	216	WP_045178742.1	hypothetical protein	-
MUA25_RS07460 (MUA25_07455)	1556001..1556492	-	492	WP_252559491.1	staphylokinase	-
MUA25_RS07465 (MUA25_07460)	1556682..1557437	-	756	WP_252559490.1	CHAP domain-containing protein	-
MUA25_RS07470 (MUA25_07465)	1557449..1557703	-	255	WP_238522769.1	phage holin	-
MUA25_RS07475 (MUA25_07470)	1557755..1557855	+	101	Protein_1466	hypothetical protein	-
-	1557792..1557848	+	57	-	-	Antitoxin
MUA25_RS07480 (MUA25_07475)	1557907..1558083	-	177	WP_252559492.1	type I toxin-antitoxin system toxin PepG1	Toxin
MUA25_RS07485 (MUA25_07480)	1558284..1559063	-	780	WP_000746437.1	exotoxin	-
MUA25_RS07490 (MUA25_07485)	1559518..1559892	-	375	WP_252559488.1	hypothetical protein	-
MUA25_RS07495 (MUA25_07490)	1559948..1560235	-	288	WP_162636283.1	hypothetical protein	-
MUA25_RS07500 (MUA25_07495)	1560281..1560433	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / sea / gnd	1554973..1624339	69366

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6818.48 Da
• Isoelectric Point: 10.9678

>T240541 WP_252559492.1 NZ_CP094801:c1558083-1557907 [Staphylococcus aureus]
MDRWRLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSIKK

Nucleotide

• Length: 177 bp

>T240541 NZ_LT591907:2355-2633 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT240541 NZ_CP094801:1557792-1557848 [Staphylococcus aureus]
AAAAGGGCAACATGCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin