Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2478188..2478705 Replicon chromosome
Accession NZ_CP094800
Organism Staphylococcus aureus strain IVB6158

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA38_RS12380 Protein ID WP_000113259.1
Coordinates 2478188..2478454 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA38_RS12385 Protein ID WP_000584500.1
Coordinates 2478454..2478705 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA38_RS12350 (2473358) 2473358..2473894 - 537 WP_000185899.1 GNAT family N-acetyltransferase -
MUA38_RS12355 (2474394) 2474394..2475218 - 825 WP_000594633.1 formate/nitrite transporter family protein -
MUA38_RS12360 (2475421) 2475421..2475603 - 183 WP_000079140.1 hypothetical protein -
MUA38_RS12365 (2475690) 2475690..2476157 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA38_RS12370 (2476343) 2476343..2477893 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA38_RS12375 (2478082) 2478082..2478171 - 90 Protein_2392 hypothetical protein -
MUA38_RS12380 (2478188) 2478188..2478454 - 267 WP_000113259.1 Txe/YoeB family addiction module toxin Toxin
MUA38_RS12385 (2478454) 2478454..2478705 - 252 WP_000584500.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA38_RS12390 (2478869) 2478869..2478949 - 81 WP_224085678.1 hypothetical protein -
MUA38_RS12395 (2478977) 2478977..2479576 - 600 WP_000162810.1 DsbA family protein -
MUA38_RS12400 (2479595) 2479595..2479957 - 363 WP_000819848.1 DUF4467 domain-containing protein -
MUA38_RS12405 (2480212) 2480212..2481462 + 1251 WP_262633502.1 FemA/FemB family glycyltransferase FmhA -
MUA38_RS12410 (2481559) 2481559..2482290 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUA38_RS12415 (2482287) 2482287..2483006 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10464.08 Da        Isoelectric Point: 10.2538

>T240536 WP_000113259.1 NZ_CP094800:c2478454-2478188 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240536 NZ_LT591902:8802-10007 [Neisseria gonorrhoeae]
ATGGTAAAACTGTCTAGCGATATTAATCTGAGAGATTTTGGCAATAACGAATATTTGTCTTCCGTTCAGGATGAGGCCAT
CCGTTTTGCGACCGAACAAACAGACGAGATATTGTCTTTATATAGCCAACATGCAGATACAGAAGGCGGTAGATATGTTT
GTGCTGATACGTTTAAAGAGTTGTTTCCAGCTTTTGAGAACAAAGAAGACAGGGCAACGGTTAATAATGCCATCCACAAT
TCAGCAGCAGTTTTATCTTCTACCCAGTTTGACGAGGTACTGAAACGCGACGAGCCACAGAAGAAAGAAGTTATTTTCGT
TACGGGAATTCCGGGTTCGGGAAAAACTTCGACAGTAAAAAACATGATGATGCAGGATACCACCAAGCTGCTTTTTGAAG
GACAGCTTGCACGGCCGCAGTCTGCTTTTCGCAAGATTGAGCAGTGTCTGGAGCGTAATCTTGAAGTTACTATCGTAGCC
GTCAGCATGAGGGCTGAAAGGGCTTCCGACAATACTTACAAACGGTTTAACGAATACGGCAGGGAAGCCAGTATAGGTAT
TATGGCTGATATTCAGGCCAATCTTCCTGACGGACTCAAGCAAATCAGGGATAAGTTTGGTGATGCGGTAAAAATTGTCG
GTATCAACCAAGACAGGAACAGTGAATTTATCGACAAGTTCGATGATGTCATCAAAATGCTTTCCTTGGGGTCGCAAGAG
CAAATATTGGGCAGGTTGGCCGAGAAAATCCAGAGCGACTTCGACTCAGGAAAAATCAGCCGGGAATGCTTCAATCAGGC
CAAGGGCAGTATGGATCTTGAAAGTGTTTTCGCCAAAAAAGAGTATTCCCAGCAAAGGGTAGTTACTAACTCCAAGGGTG
TTACCCTAGAAACAAAGTCAGCAAACGAGTTGTGGTCTAAGGTGGAACAAATTCCTGTAACAGGCATGAAAGCCGGTATC
TATTTACTAGGTCAAGCTAAAAAAGCAGAGACTGGTCAAACTTATTCCGGAGAAATCATTTACAAGGATGCCGCTGCGGT
ATTTCAAAAAACCAAAAACGGGCTTGTCAGGCACAATGCAACACATAACGAAGAAAGACTGGCCAAATTGGTTGAGATAG
GGCAGAACGTTTCTATCGGAAGCAATAAGGGCAAATTGATTGTCAAGTCTTTGGAGTATTCCGCCAAAAAATCCATCAGC
AGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9419.58 Da        Isoelectric Point: 4.3407

>AT240536 WP_000584500.1 NZ_CP094800:c2478705-2478454 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT240536 NZ_LT591902:10022-10453 [Neisseria gonorrhoeae]
ATGAAAGAAAAAATGCGGTTGATCACGGAAATTTCGCTGATTATCAGGGAACTGTCTTATTCCCGGCGCGGGTATCGGCC
TGAGAGTTATGCGGCTGCGCTGGATAATTTGACGATAATCGGAGATTTGGCCGACATTTTGCACAACATCGAGGCAGCGA
CAGGCAATCCATTTGTTCAAAGGATGGTTGATGAAAAACTGAGAAAGTTTGTTACCGATTTTCCGGCTTATAAGGTACGG
TTGTCTCCGTTTTTGAATGGCTGTCCCCATGACCTTTCGTTAGGAGCAGAATCGTTGGGTAAGGGGGAGAGTATCGCTGA
TGCCTTGGCCGTTCCTCCGGAAGAGGTAGATATTGCAGACATTGAGTTTGACCGTGTGCTTATCGAAGACGACCGTTGGA
CAGGAGCATATGATGGTGGTAACGCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References