Detailed information of TA system TA240529

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1901980..1902206
• Replicon: chromosome
• Accession: NZ_CP094800
• Organism: Staphylococcus aureus strain IVB6158

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: MUA38_RS09120
• Protein ID: WP_057488488.1
• Coordinates: 1902102..1902206 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1901980..1902073 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA38_RS09070 (1897246)	1897246..1897446	-	201	WP_000498228.1	hypothetical protein	-
MUA38_RS09075 (1897460)	1897460..1897669	-	210	WP_262633435.1	hypothetical protein	-
MUA38_RS09080 (1898221)	1898221..1898949	-	729	WP_100066918.1	DUF3800 domain-containing protein	-
MUA38_RS09085 (1899286)	1899286..1899471	-	186	WP_001286805.1	hypothetical protein	-
MUA38_RS09090 (1899473)	1899473..1899583	-	111	WP_000139425.1	hypothetical protein	-
MUA38_RS09095 (1899654)	1899654..1899806	-	153	WP_001788502.1	hypothetical protein	-
MUA38_RS09100 (1900196)	1900196..1900687	-	492	WP_250406032.1	staphylokinase	-
MUA38_RS09105 (1900878)	1900878..1901633	-	756	WP_262633437.1	CHAP domain-containing protein	-
MUA38_RS09110 (1901645)	1901645..1901899	-	255	WP_000611512.1	phage holin	-
MUA38_RS09115 (1901951)	1901951..1902046	+	96	Protein_1793	hypothetical protein	-
- (1901980)	1901980..1902073	+	94	NuclAT_1	-	Antitoxin
- (1901980)	1901980..1902073	+	94	NuclAT_1	-	Antitoxin
- (1901980)	1901980..1902073	+	94	NuclAT_1	-	Antitoxin
- (1901980)	1901980..1902073	+	94	NuclAT_1	-	Antitoxin
MUA38_RS09120 (1902102)	1902102..1902206	-	105	WP_057488488.1	hypothetical protein	Toxin
MUA38_RS09125 (1902412)	1902412..1902711	-	300	WP_107240626.1	DUF2951 family protein	-
MUA38_RS09130 (1902750)	1902750..1902911	-	162	WP_250406035.1	hypothetical protein	-
MUA38_RS09135 (1902898)	1902898..1905084	-	2187	WP_262633440.1	phage tail protein	-
MUA38_RS09140 (1905100)	1905100..1906215	-	1116	WP_262633442.1	hypothetical protein	-
MUA38_RS09145 (1906232)	1906232..1907185	-	954	WP_250425907.1	phage tail family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / sak	1880174..1937883	57709

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3919.77 Da
• Isoelectric Point: 5.5724

>T240529 WP_057488488.1 NZ_CP094800:c1902206-1902102 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISNQDHKK

Nucleotide

• Length: 105 bp

>T240529 NZ_LT591897:c1562685-1562413 [Neisseria gonorrhoeae]
ATGCAAATTAATTGGTCAACAGAAGCCAATGAAGATTTGAATGAGATAACGGATTTCATCGCAGACGATAGCCCCGTTGC
AGCAGTTAATTTGTCTGAGCATTTGTTTGAAACTGCCGAAAAAATCGGACAGATGCCATACATGGGGCGAAAAGGTCGTG
TAGCAGGAACACGGGAATTTGTAGCTCACCCAAACTACATTTTGGTCTATCAGGTCAAATTGGACGAAATTAGGATTTTG
AGGGTGCTTCATGGAAGCAGGAAATACCCTTAA

Antitoxin

Nucleotide

• Length: 94 bp

>AT240529 NZ_CP094800:1901980-1902073 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTTTTCATAGAAAAA
TTATAAAAATAACC

Structures

Antitoxin