Detailed information of TA system TA240527

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1873123..1873303
• Replicon: chromosome
• Accession: NZ_CP094800
• Organism: Staphylococcus aureus strain IVB6158

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA38_RS08960
• Protein ID: WP_001801861.1
• Coordinates: 1873123..1873218 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1873246..1873303 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA38_RS08930	1868189..1868761	+	573	WP_250426005.1	hypothetical protein	-
MUA38_RS08935	1869243..1869974	+	732	WP_250426010.1	ATP-binding cassette domain-containing protein	-
MUA38_RS08940	1870781..1870966	-	186	WP_000809858.1	hypothetical protein	-
MUA38_RS08945	1870968..1871144	-	177	WP_000375476.1	hypothetical protein	-
MUA38_RS08950	1871155..1871538	-	384	WP_000070811.1	hypothetical protein	-
MUA38_RS08955	1872225..1872671	-	447	WP_000747809.1	DUF1433 domain-containing protein	-
MUA38_RS08960	1873123..1873218	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1873246..1873303	-	58	-	-	Antitoxin
MUA38_RS08965	1873341..1873442	+	102	WP_001791232.1	hypothetical protein	-
MUA38_RS08970	1873480..1873596	-	117	Protein_1764	transposase	-
MUA38_RS08975	1874105..1878219	-	4115	Protein_1765	SMEK domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240527 WP_001801861.1 NZ_CP094800:1873123-1873218 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240527 NZ_LT591897:c1044579-1044307 [Neisseria gonorrhoeae]
ATGCAAATTAATTGGTCAACAGAAGCCAATGAAGATTTGAATGAGATAACGGATTTCATCGCAGACGATAGCCCCGTTGC
AGCAGTTAATTTGTCTGAGCATTTGTTTGAAACTGCCGAAAAAATCGGACAGATGCCATACATGGGGCGAAAAGGTCGTG
TAGCAGGAACACGGGAATTTGTAGCTCACCCAAACTACATTTTGGTCTATCAGGTCAAATTGGACGAAATTAGGATTTTG
AGGGTGCTTCATGGAAGCAGGAAATACCCTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240527 NZ_CP094800:c1873303-1873246 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin