Detailed information of TA system TA240524

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 373075..373596
• Replicon: chromosome
• Accession: NZ_CP094800
• Organism: Staphylococcus aureus strain IVB6158

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A2S6DEP6
• Locus tag: MUA38_RS01690
• Protein ID: WP_000339141.1
• Coordinates: 373294..373596 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	373075..373214 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA38_RS01650 (368181)	368181..368471	+	291	WP_000179864.1	hypothetical protein	-
MUA38_RS01655 (368487)	368487..370397	+	1911	WP_250406127.1	hypothetical protein	-
MUA38_RS01660 (370397)	370397..371863	+	1467	WP_250425823.1	BppU family phage baseplate upper protein	-
MUA38_RS01665 (371863)	371863..372252	+	390	WP_250406125.1	DUF2977 domain-containing protein	-
MUA38_RS01670 (372245)	372245..372409	+	165	WP_000916021.1	XkdX family protein	-
MUA38_RS01675 (372455)	372455..372754	+	300	WP_000466774.1	DUF2951 family protein	-
MUA38_RS01680 (372907)	372907..373083	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	-
- (373075)	373075..373214	-	140	NuclAT_0	-	Antitoxin
- (373075)	373075..373214	-	140	NuclAT_0	-	Antitoxin
- (373075)	373075..373214	-	140	NuclAT_0	-	Antitoxin
- (373075)	373075..373214	-	140	NuclAT_0	-	Antitoxin
MUA38_RS01685 (373136)	373136..373243	-	108	WP_042900009.1	hypothetical protein	-
MUA38_RS01690 (373294)	373294..373596	+	303	WP_000339141.1	phage holin	Toxin
MUA38_RS01695 (373607)	373607..375061	+	1455	WP_250425827.1	N-acetylmuramoyl-L-alanine amidase	-
MUA38_RS01700 (376157)	376157..376543	+	387	WP_228480554.1	hypothetical protein	-
MUA38_RS01705 (377103)	377103..377930	-	828	WP_000136010.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh / geh	324330..375061	50731

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11174.92 Da
• Isoelectric Point: 9.6413

>T240524 WP_000339141.1 NZ_CP094800:373294-373596 [Staphylococcus aureus]
MDAKVITRYIVLILALVNQFLANKGISPIPVDDETISSIILTVVALYTTYKDNPTSQEGKWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T240524 NZ_LT578453:c944259-943399 [Mycoplasma bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATCAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT240524 NZ_CP094800:c373214-373075 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A2S6DEP6

Antitoxin