Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2503489..2503673 Replicon chromosome
Accession NZ_CP094799
Organism Staphylococcus aureus strain IVB6159

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUA85_RS12510 Protein ID WP_000482647.1
Coordinates 2503566..2503673 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2503489..2503549 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA85_RS12495 2498943..2499110 - 168 WP_031901225.1 hypothetical protein -
MUA85_RS12500 2499341..2501074 - 1734 Protein_2417 ABC transporter ATP-binding protein/permease -
MUA85_RS12505 2501099..2502862 - 1764 WP_250425583.1 ABC transporter ATP-binding protein -
- 2503489..2503549 + 61 - - Antitoxin
MUA85_RS12510 2503566..2503673 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA85_RS12515 2503807..2504193 - 387 WP_000779350.1 flippase GtxA -
MUA85_RS12520 2504461..2505603 + 1143 WP_001176867.1 glycerate kinase -
MUA85_RS12525 2505663..2506322 + 660 WP_000831298.1 membrane protein -
MUA85_RS12530 2506505..2507716 + 1212 WP_250425584.1 multidrug effflux MFS transporter -
MUA85_RS12535 2507839..2508312 - 474 WP_000456488.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T240518 WP_000482647.1 NZ_CP094799:c2503673-2503566 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240518 NZ_LT578417:1518257-1518532 [Cyanobium sp. NIES-981]
ATGCAGGTGGTGAGCTTTTCAGAGGCCCGGGAGAGTTTCAAGGCCGTGCTGGATCGGGTGGAGGCCGATGCCGACGTGAC
CCTCATCACCCGGAGGCACGCCAAGGGGGCGGTGGTGATGTCGCTCGACACCTACAACAGCCTGATGGAAACCGTGCATC
TGCTGCGTTCCCCGGCCAATGCGGCCCATCTGCAGCGGTCACTGGAGCAGGCCGGGCGCGGGGAGCTTCTCTCCCATGGG
CTGATCGATCCGGATGTGGCCGATGGCGGCGATTGA

Antitoxin


Download         Length: 61 bp

>AT240518 NZ_CP094799:2503489-2503549 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References