Detailed information of TA system TA240517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2478185..2478702
• Replicon: chromosome
• Accession: NZ_CP094799
• Organism: Staphylococcus aureus strain IVB6159

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUA85_RS12375
• Protein ID: WP_000113259.1
• Coordinates: 2478185..2478451 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MUA85_RS12380
• Protein ID: WP_000584500.1
• Coordinates: 2478451..2478702 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA85_RS12345 (2473355)	2473355..2473891	-	537	WP_000185899.1	GNAT family N-acetyltransferase	-
MUA85_RS12350 (2474391)	2474391..2475215	-	825	WP_000594633.1	formate/nitrite transporter family protein	-
MUA85_RS12355 (2475418)	2475418..2475600	-	183	WP_000079140.1	hypothetical protein	-
MUA85_RS12360 (2475687)	2475687..2476154	-	468	WP_000153340.1	SRPBCC domain-containing protein	-
MUA85_RS12365 (2476340)	2476340..2477890	-	1551	WP_000727763.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MUA85_RS12370 (2478079)	2478079..2478168	-	90	Protein_2391	hypothetical protein	-
MUA85_RS12375 (2478185)	2478185..2478451	-	267	WP_000113259.1	Txe/YoeB family addiction module toxin	Toxin
MUA85_RS12380 (2478451)	2478451..2478702	-	252	WP_000584500.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA85_RS12385 (2478866)	2478866..2478946	-	81	WP_224085678.1	hypothetical protein	-
MUA85_RS12390 (2478974)	2478974..2479573	-	600	WP_000162810.1	DsbA family protein	-
MUA85_RS12395 (2479592)	2479592..2479954	-	363	WP_000819848.1	DUF4467 domain-containing protein	-
MUA85_RS12400 (2480209)	2480209..2481459	+	1251	WP_262633502.1	FemA/FemB family glycyltransferase FmhA	-
MUA85_RS12405 (2481556)	2481556..2482287	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
MUA85_RS12410 (2482284)	2482284..2483003	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10464.08 Da
• Isoelectric Point: 10.2538

>T240517 WP_000113259.1 NZ_CP094799:c2478451-2478185 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T240517 NZ_LT578417:1508237-1508599 [Cyanobium sp. NIES-981]
CTGATGCTGCTGCTTGACACCAACCTGCTGATCGACGTGCTGCGGGGCGAGGCGGTGGCCCTGCGCTGGCTGGCGGAGCA
GCAGCGTCCGAGCATCAGCGTGATCACCTGGATCGAGGTGCTGGTGGGCTGCCGCCAGGGGGAGCAGGAACGGGTGGAGG
GTTGGCTGCAGGCGTTCCCGCGCCTGCCGCTGGATCAGGCCGTTGCCCGCGAATCGGTGCTGCTGCGGCAACGCCACGGG
TTGAAGGTGCCCGACGCGATCATCCTGGCCACGGCCCGATGCGCCGGTCTCACCCTGGCCACCCGCAACGTGCGCGATTT
CCCGCTGGAACTCGGGGACGTGCTGCACCCTTACACCCTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9419.58 Da
• Isoelectric Point: 4.3407

>AT240517 WP_000584500.1 NZ_CP094799:c2478702-2478451 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Nucleotide

• Length: 252 bp

>AT240517 NZ_LT578417:1508019-1508240 [Cyanobium sp. NIES-981]
ATGCGCACGATCGTGGACCTGCCGGAGCCGGAGCGGGCCCAGCTCGATGCCCTGTGCCGGCAGCGCGGCATCTCCCGGGC
CCAGGCGCTGCGCGAAGCCCTGAGCCAGTGGCTGGAGCAGCAGCGGCCGCAGCATGAGCAGGTGTTCGGCCTCTGGCGCG
ACCGGCCCGAGGGCTCCCTGGATCTGCAGGAGGCGCTCCGCAGCGAGTGGGCCGGCCGCTGA