Detailed information of TA system TA240508

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1873120..1873300
• Replicon: chromosome
• Accession: NZ_CP094799
• Organism: Staphylococcus aureus strain IVB6159

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA85_RS08955
• Protein ID: WP_001801861.1
• Coordinates: 1873120..1873215 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1873243..1873300 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA85_RS08925	1868186..1868758	+	573	WP_250426005.1	hypothetical protein	-
MUA85_RS08930	1869240..1869971	+	732	WP_250426010.1	ATP-binding cassette domain-containing protein	-
MUA85_RS08935	1870778..1870963	-	186	WP_000809858.1	hypothetical protein	-
MUA85_RS08940	1870965..1871141	-	177	WP_000375476.1	hypothetical protein	-
MUA85_RS08945	1871152..1871535	-	384	WP_000070811.1	hypothetical protein	-
MUA85_RS08950	1872222..1872668	-	447	WP_000747809.1	DUF1433 domain-containing protein	-
MUA85_RS08955	1873120..1873215	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1873243..1873300	-	58	-	-	Antitoxin
MUA85_RS08960	1873338..1873439	+	102	WP_001791232.1	hypothetical protein	-
MUA85_RS08965	1873477..1873593	-	117	Protein_1763	transposase	-
MUA85_RS08970	1874102..1878216	-	4115	Protein_1764	SMEK domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240508 WP_001801861.1 NZ_CP094799:1873120-1873215 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240508 NZ_LT571436:1852048-1852449 [Neisseria weaveri]
ATGCTTCGCTATATGCTTGATACCAATATCTGCATTTACACGATTAAAAACAATCCCGCAGCAGTGCGCGAAAAGTTCCA
ACAGCATCAGCATCATATGTGCATCAGCAGCATTGTGCTGACCGAACTGCTGTATGGTGCTGAAAAATCAAGCAATCCGG
CCAAATCACTAGCCTTAGTTGAAGGTATGGCGGCACGATTGGAAGTATTGAATTTTGATGAAACTGCTGCTGCCCACGCT
GCGGAAATCCGTGCTGATCTTACCCGAAAAGGTACGCCAATCGGACACTATGATGTTTTGATTGCCGGCCATGCCCGCAG
CCGCGGTTTGATATTGGTCAGCAATAACCTGCGGGAATTTGAGCGGGTAGCGGGGTTAAGGTTGGAGAACTGGGCAGTTT
GA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240508 NZ_CP094799:c1873300-1873243 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin