Detailed information of TA system TA240501

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 372907..373245
• Replicon: chromosome
• Accession: NZ_CP094799
• Organism: Staphylococcus aureus strain IVB6159

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: MUA85_RS01680
• Protein ID: WP_072357969.1
• Coordinates: 372907..373083 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	373071..373245 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA85_RS01650	368181..368471	+	291	WP_000179864.1	hypothetical protein	-
MUA85_RS01655	368487..370397	+	1911	WP_250406127.1	hypothetical protein	-
MUA85_RS01660	370397..371863	+	1467	WP_250425823.1	BppU family phage baseplate upper protein	-
MUA85_RS01665	371863..372252	+	390	WP_250406125.1	DUF2977 domain-containing protein	-
MUA85_RS01670	372245..372409	+	165	WP_000916021.1	XkdX family protein	-
MUA85_RS01675	372455..372754	+	300	WP_000466774.1	DUF2951 family protein	-
MUA85_RS01680	372907..373083	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	373071..373245	-	175	-	-	Antitoxin
MUA85_RS01690	373294..373596	+	303	WP_000339141.1	phage holin	-
MUA85_RS01695	373607..375061	+	1455	WP_250425827.1	N-acetylmuramoyl-L-alanine amidase	-
MUA85_RS01700	376157..376543	+	387	WP_228480554.1	hypothetical protein	-
MUA85_RS01705	377103..377930	-	828	WP_000136010.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	328882..375061	46179

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T240501 WP_072357969.1 NZ_CP094799:372907-373083 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T240501 NZ_LT556085:2502331-2502699 [Citrobacter amalonaticus]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT240501 NZ_CP094799:c373245-373071 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin