Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2512664..2513187 Replicon chromosome
Accession NZ_CP094797
Organism Staphylococcus aureus strain IVB6163

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag MUA16_RS12555 Protein ID WP_000074047.1
Coordinates 2512664..2512930 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag MUA16_RS12560 Protein ID WP_000587617.1
Coordinates 2512930..2513187 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA16_RS12535 (2507874) 2507874..2509061 - 1188 WP_000026190.1 MFS transporter -
MUA16_RS12540 (2509455) 2509455..2510231 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
MUA16_RS12545 (2510224) 2510224..2510886 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
MUA16_RS12550 (2511232) 2511232..2512308 - 1077 WP_001076679.1 M42 family metallopeptidase -
MUA16_RS12555 (2512664) 2512664..2512930 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
MUA16_RS12560 (2512930) 2512930..2513187 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA16_RS12565 (2513547) 2513547..2514002 + 456 WP_000732090.1 YehR family lipoprotein -
MUA16_RS12570 (2514170) 2514170..2515747 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
MUA16_RS12575 (2515943) 2515943..2516692 + 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA16_RS12580 (2516916) 2516916..2518109 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T240500 WP_000074047.1 NZ_CP094797:c2512930-2512664 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240500 NZ_LT556085:1933143-1933520 [Citrobacter amalonaticus]
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT240500 WP_000587617.1 NZ_CP094797:c2513187-2512930 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240500 NZ_LT556085:1932766-1933092 [Citrobacter amalonaticus]
ATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTTTGGCGCACGGCTGGTACAGGCGGGCAACCGTCT
GCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACGCTGATTTACGGTATCTCGACCAGGCATTTCCAC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCTGCCATCAGCACTGTGTCACGCTCTATGCA
AAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGTATACCTGGCGATTTATCCGACACCAGCGGCAAC
CGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References