Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2456046..2456563 Replicon chromosome
Accession NZ_CP094797
Organism Staphylococcus aureus strain IVB6163

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag MUA16_RS12280 Protein ID WP_000251928.1
Coordinates 2456046..2456312 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag MUA16_RS12285 Protein ID WP_000584497.1
Coordinates 2456312..2456563 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA16_RS12255 (2451253) 2451253..2451789 - 537 WP_262519359.1 GNAT family N-acetyltransferase -
MUA16_RS12260 (2452257) 2452257..2453081 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA16_RS12265 (2453284) 2453284..2453466 - 183 WP_000079140.1 hypothetical protein -
MUA16_RS12270 (2453553) 2453553..2454020 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA16_RS12275 (2454206) 2454206..2455753 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA16_RS12280 (2456046) 2456046..2456312 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
MUA16_RS12285 (2456312) 2456312..2456563 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA16_RS12290 (2456727) 2456727..2456827 - 101 Protein_2375 hypothetical protein -
MUA16_RS12295 (2456834) 2456834..2457433 - 600 WP_000162804.1 DsbA family protein -
MUA16_RS12300 (2457452) 2457452..2457814 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA16_RS12305 (2458069) 2458069..2459319 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
MUA16_RS12310 (2459416) 2459416..2460147 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
MUA16_RS12315 (2460144) 2460144..2460863 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T240497 WP_000251928.1 NZ_CP094797:c2456312-2456046 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240497 NZ_LT556085:c462390-462049 [Citrobacter amalonaticus]
ATGAAAATTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGCCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGCCTGACCCTGAACGATACGCCGTTCAGTGATGAAATCGTTATAAAGGAACATATCG
ATGCCGGTATCACGCTGGCCGATGCCGTTAACTTTCTGGTGGAAAAATACGAGCTGGTTCGAATAGATCGCAAAGGATTT
AGTTGGCAGGAACAATCCCCGTATCTTCGGGCTGTAGATATTCTGCGGGCAAGACAGGCAACTGGCCTGTTGCGACAAAG
CCGTAACAACGCAGTACGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT240497 WP_000584497.1 NZ_CP094797:c2456563-2456312 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT240497 NZ_LT556085:c462728-462411 [Citrobacter amalonaticus]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGTATCACCGGTAAATTCAGTGATGCCGAATGTCTTAAGCTGGATGTGGCATTCCCGC
ACTTTATCAGCCAGATCGAGTCGATGCTGACCACCTATGAACTGAATCCCCGACACGCCCACTGCGTCACCCTGTGCCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTATGTATACGTCGCTGTTTATTCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References