Detailed information of TA system TA240482

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2466650..2467173
• Replicon: chromosome
• Accession: NZ_CP094795
• Organism: Staphylococcus aureus strain IVB6164

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: X5DYX7
• Locus tag: MUA75_RS12180
• Protein ID: WP_000074048.1
• Coordinates: 2466650..2466916 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MUA75_RS12185
• Protein ID: WP_252549875.1
• Coordinates: 2466916..2467173 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA75_RS12160 (MUA75_12150)	2461869..2463056	-	1188	WP_000026189.1	MFS transporter	-
MUA75_RS12165 (MUA75_12155)	2463451..2464227	-	777	WP_262629830.1	iron export ABC transporter permease subunit FetB	-
MUA75_RS12170 (MUA75_12160)	2464220..2464882	-	663	WP_000923508.1	ATP-binding cassette domain-containing protein	-
MUA75_RS12175 (MUA75_12165)	2465227..2466294	-	1068	WP_001076685.1	M42 family metallopeptidase	-
MUA75_RS12180 (MUA75_12170)	2466650..2466916	-	267	WP_000074048.1	Txe/YoeB family addiction module toxin	Toxin
MUA75_RS12185 (MUA75_12175)	2466916..2467173	-	258	WP_252549875.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA75_RS12190 (MUA75_12180)	2467533..2467988	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
MUA75_RS12195 (MUA75_12185)	2468156..2469733	-	1578	WP_262629832.1	FMN-binding glutamate synthase family protein	-
MUA75_RS12200 (MUA75_12190)	2469927..2470676	+	750	WP_000072456.1	CPBP family lipoprotein N-acylation protein LnsB	-
MUA75_RS12205 (MUA75_12195)	2470900..2472093	-	1194	WP_252549877.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10648.23 Da
• Isoelectric Point: 10.1384

>T240482 WP_000074048.1 NZ_CP094795:c2466916-2466650 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T240482 NZ_LT549890:c1721653-1721039 [Saccharolobus solfataricus]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9748.69 Da
• Isoelectric Point: 4.0717

>AT240482 WP_252549875.1 NZ_CP094795:c2467173-2466916 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNDNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT240482 NZ_LT549890:c1722018-1721671 [Saccharolobus solfataricus]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Structures

Toxin

• PDB: 7V6W
• PDB: 7V5Y
• PDB: 7V5Z