Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2435343..2435527 Replicon chromosome
Accession NZ_CP094795
Organism Staphylococcus aureus strain IVB6164

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUA75_RS12040 Protein ID WP_000482647.1
Coordinates 2435420..2435527 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2435343..2435403 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA75_RS12025 (MUA75_12015) 2430797..2430964 - 168 WP_031927726.1 hypothetical protein -
MUA75_RS12030 (MUA75_12020) 2431195..2432928 - 1734 WP_000486497.1 ABC transporter ATP-binding protein -
MUA75_RS12035 (MUA75_12025) 2432953..2434716 - 1764 WP_252549861.1 ABC transporter ATP-binding protein -
- 2435343..2435403 + 61 - - Antitoxin
MUA75_RS12040 (MUA75_12030) 2435420..2435527 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA75_RS12045 (MUA75_12035) 2435661..2436047 - 387 WP_000779353.1 flippase GtxA -
MUA75_RS12050 (MUA75_12040) 2436315..2437457 + 1143 WP_001176867.1 glycerate kinase -
MUA75_RS12055 (MUA75_12045) 2437517..2438176 + 660 WP_000831298.1 membrane protein -
MUA75_RS12060 (MUA75_12050) 2438359..2439570 + 1212 WP_001191927.1 multidrug effflux MFS transporter -
MUA75_RS12065 (MUA75_12055) 2439693..2440166 - 474 WP_000456493.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T240480 WP_000482647.1 NZ_CP094795:c2435527-2435420 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240480 NZ_CP094795:c2435527-2435420 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT240480 NZ_CP094795:2435343-2435403 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References