Detailed information of TA system TA240479

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2409971..2410488
• Replicon: chromosome
• Accession: NZ_CP094795
• Organism: Staphylococcus aureus strain IVB6164

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUA75_RS11905
• Protein ID: WP_000113260.1
• Coordinates: 2409971..2410237 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: MUA75_RS11910
• Protein ID: WP_000584499.1
• Coordinates: 2410237..2410488 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA75_RS11875 (MUA75_11865)	2405123..2405659	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
MUA75_RS11880 (MUA75_11870)	2406181..2407005	-	825	WP_000594633.1	formate/nitrite transporter family protein	-
MUA75_RS11885 (MUA75_11875)	2407208..2407390	-	183	WP_000079140.1	hypothetical protein	-
MUA75_RS11890 (MUA75_11880)	2407477..2407944	-	468	WP_000153340.1	SRPBCC domain-containing protein	-
MUA75_RS11895 (MUA75_11885)	2408130..2409677	-	1548	WP_262629819.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MUA75_RS11900 (MUA75_11890)	2409856..2409936	-	81	WP_225539491.1	hypothetical protein	-
MUA75_RS11905 (MUA75_11895)	2409971..2410237	-	267	WP_000113260.1	Txe/YoeB family addiction module toxin	Toxin
MUA75_RS11910 (MUA75_11900)	2410237..2410488	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA75_RS11915 (MUA75_11905)	2410653..2410733	-	81	WP_225539489.1	hypothetical protein	-
MUA75_RS11920 (MUA75_11910)	2410761..2411360	-	600	WP_000162810.1	DsbA family protein	-
MUA75_RS11925 (MUA75_11915)	2411379..2411741	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
MUA75_RS11930 (MUA75_11920)	2411996..2413246	+	1251	WP_001012239.1	FemA/FemB family glycyltransferase FmhA	-
MUA75_RS11935 (MUA75_11925)	2413343..2414074	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
MUA75_RS11940 (MUA75_11930)	2414071..2414790	-	720	WP_000479579.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.99 Da
• Isoelectric Point: 10.0373

>T240479 WP_000113260.1 NZ_CP094795:c2410237-2409971 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T240479 NZ_LT549890:1432822-1433211 [Saccharolobus solfataricus]
ATGATAGTAGTTGATACGAATGTCCTAATTTACGCCACTCTTGAAGACAGCGAATTTCATACTCAAAGTCTAGAGATAAT
TGAGGGATCAGACATAATAGTTCCCCAAATTGTAGTCTTCGAATACATAAAGGTACTATCTGAAATTGTACAGAACTTAG
ATTTCATAAAAACAAAAATCTCAGAGTTAAACAATTTTGTCGTTGTTTGCGAAGACCTTAATACTATAGCACTAGCGTTG
AGACTATTAGCAGAGTTAAAACTTTCACTGAAAGACATTAACGATATGATAATCTTAACCGCAGCAATTAAGACAAACAG
CTCCATAGCCACATTTGATCAGAAGCTTAGAAAGATTGCAGACAAGAAGGGAGTTAAAGTTTTGCCTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT240479 WP_000584499.1 NZ_CP094795:c2410488-2410237 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT240479 NZ_LT549890:1432611-1432835 [Saccharolobus solfataricus]
ATGATATCTAAGGTCACCAGGAACTTTCAAGTCACAATTCCTTATGAGATTAGAAAAGTGCTAGGAATAAAAGAGGGAGA
CTATATTGAGTTCGCAATAGAAAACGGTAAGGTCATGATAAAACCTGTTAGAAAAGTTTGGTCAACTATTAGACTTGGAA
GAGAAGTTACAGTGGAGGAGATTGAGGAAATCGCAAGTAAGGCCTTTAAAGATGATAGTAGTTGA

Structures

Antitoxin

• AlphaFold DB: T1YB60