Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 348178..348592 | Replicon | chromosome |
| Accession | NZ_CP094795 | ||
| Organism | Staphylococcus aureus strain IVB6164 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | MUA75_RS01565 | Protein ID | WP_110166336.1 |
| Coordinates | 348178..348429 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MUA75_RS01570 | Protein ID | WP_000028424.1 |
| Coordinates | 348419..348592 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA75_RS01500 (MUA75_01495) | 343495..344127 | + | 633 | WP_262629984.1 | ATP-binding protein | - |
| MUA75_RS01505 (MUA75_01500) | 344124..344284 | + | 161 | Protein_298 | hypothetical protein | - |
| MUA75_RS01510 (MUA75_01505) | 344297..344518 | + | 222 | WP_001123695.1 | DUF3269 family protein | - |
| MUA75_RS01515 (MUA75_01510) | 344529..344933 | + | 405 | WP_000049784.1 | DUF1064 domain-containing protein | - |
| MUA75_RS01520 (MUA75_01515) | 344938..345123 | + | 186 | WP_001187242.1 | DUF3113 family protein | - |
| MUA75_RS01525 (MUA75_01520) | 345124..345741 | + | 618 | WP_262529389.1 | SA1788 family PVL leukocidin-associated protein | - |
| MUA75_RS01530 (MUA75_01525) | 345741..345998 | + | 258 | WP_031864864.1 | DUF3310 domain-containing protein | - |
| MUA75_RS01535 (MUA75_01530) | 346001..346201 | + | 201 | WP_252549766.1 | hypothetical protein | - |
| MUA75_RS01540 (MUA75_01535) | 346198..346887 | + | 690 | WP_252549763.1 | N-6 DNA methylase | - |
| MUA75_RS01545 (MUA75_01540) | 346901..347107 | + | 207 | WP_252549760.1 | hypothetical protein | - |
| MUA75_RS01550 (MUA75_01545) | 347135..347536 | + | 402 | WP_252549758.1 | hypothetical protein | - |
| MUA75_RS01555 (MUA75_01550) | 347533..347880 | + | 348 | WP_252570428.1 | YopX family protein | - |
| MUA75_RS01560 (MUA75_01555) | 347877..348098 | + | 222 | Protein_309 | hypothetical protein | - |
| MUA75_RS01565 (MUA75_01560) | 348178..348429 | + | 252 | WP_110166336.1 | DUF1024 family protein | Toxin |
| MUA75_RS01570 (MUA75_01565) | 348419..348592 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| MUA75_RS01575 (MUA75_01570) | 348593..348874 | + | 282 | WP_000454994.1 | hypothetical protein | - |
| MUA75_RS01580 (MUA75_01575) | 348875..349036 | + | 162 | WP_000889683.1 | hypothetical protein | - |
| MUA75_RS01585 (MUA75_01580) | 349051..349584 | + | 534 | WP_025920701.1 | dUTP diphosphatase | - |
| MUA75_RS01590 (MUA75_01585) | 349621..349827 | + | 207 | WP_033859700.1 | DUF1381 domain-containing protein | - |
| MUA75_RS01595 (MUA75_01590) | 349824..349973 | + | 150 | WP_000595265.1 | transcriptional activator RinB | - |
| MUA75_RS01600 (MUA75_01595) | 349973..350173 | + | 201 | WP_111761860.1 | DUF1514 family protein | - |
| MUA75_RS01605 (MUA75_01600) | 350196..350657 | + | 462 | WP_086037675.1 | hypothetical protein | - |
| MUA75_RS01610 (MUA75_01605) | 350772..351224 | + | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| MUA75_RS01615 (MUA75_01610) | 351240..351584 | + | 345 | WP_000817289.1 | HNH endonuclease | - |
| MUA75_RS01620 (MUA75_01615) | 351713..352183 | + | 471 | WP_262629987.1 | phage terminase small subunit P27 family | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 332510..373942 | 41432 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9445.35 Da Isoelectric Point: 3.9476
>T240474 WP_110166336.1 NZ_CP094795:348178-348429 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T240474 NZ_LT222314:c41634-41362 [Pseudomonas cerasi]
GTGCTAGTTGAGTGGCTTCCACAAGCTTTGGAGGCACTGGAGGAAATCGCCGGCTACCTAGCCGAGCGCAACCCTTATGC
TGCCGAGCAGATGCAGGCCACCCTTGAGGCCACGGTCGAGGCTCTCCCCCTGCACCCTTACATCCACCGTCCCGGCCGTG
TTCCAGGAACGCGCGAAGCGGTTGTGCATCCCAACTACCTGGTTGTCTACCGCGTCGGTACAGAGCGCATCAGCATCTTG
GACGTCCTGCACGCCCGCCAAGAGTACCCCTAG
GTGCTAGTTGAGTGGCTTCCACAAGCTTTGGAGGCACTGGAGGAAATCGCCGGCTACCTAGCCGAGCGCAACCCTTATGC
TGCCGAGCAGATGCAGGCCACCCTTGAGGCCACGGTCGAGGCTCTCCCCCTGCACCCTTACATCCACCGTCCCGGCCGTG
TTCCAGGAACGCGCGAAGCGGTTGTGCATCCCAACTACCTGGTTGTCTACCGCGTCGGTACAGAGCGCATCAGCATCTTG
GACGTCCTGCACGCCCGCCAAGAGTACCCCTAG
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT240474 WP_000028424.1 NZ_CP094795:348419-348592 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT240474 NZ_LT222314:c41809-41624 [Pseudomonas cerasi]
ATGAGCATTCAACTTGACCCTCGCGTCTCGGAGTTCGAGACCCAGGAACAGGCCGACAATTACGACCGTTGGTTTCGCCA
GCGTATCGAGCACAGTTTGGCCGATCCGCGTCCACCCGTGCCGCACGATGAAGCAATGGCTCGCGTCAGAGCCATGATCG
AAGCAAAGCGCCGCCGTGCTAGTTGA
ATGAGCATTCAACTTGACCCTCGCGTCTCGGAGTTCGAGACCCAGGAACAGGCCGACAATTACGACCGTTGGTTTCGCCA
GCGTATCGAGCACAGTTTGGCCGATCCGCGTCCACCCGTGCCGCACGATGAAGCAATGGCTCGCGTCAGAGCCATGATCG
AAGCAAAGCGCCGCCGTGCTAGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|