Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 348178..348592 Replicon chromosome
Accession NZ_CP094795
Organism Staphylococcus aureus strain IVB6164

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA75_RS01565 Protein ID WP_110166336.1
Coordinates 348178..348429 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA75_RS01570 Protein ID WP_000028424.1
Coordinates 348419..348592 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA75_RS01500 (MUA75_01495) 343495..344127 + 633 WP_262629984.1 ATP-binding protein -
MUA75_RS01505 (MUA75_01500) 344124..344284 + 161 Protein_298 hypothetical protein -
MUA75_RS01510 (MUA75_01505) 344297..344518 + 222 WP_001123695.1 DUF3269 family protein -
MUA75_RS01515 (MUA75_01510) 344529..344933 + 405 WP_000049784.1 DUF1064 domain-containing protein -
MUA75_RS01520 (MUA75_01515) 344938..345123 + 186 WP_001187242.1 DUF3113 family protein -
MUA75_RS01525 (MUA75_01520) 345124..345741 + 618 WP_262529389.1 SA1788 family PVL leukocidin-associated protein -
MUA75_RS01530 (MUA75_01525) 345741..345998 + 258 WP_031864864.1 DUF3310 domain-containing protein -
MUA75_RS01535 (MUA75_01530) 346001..346201 + 201 WP_252549766.1 hypothetical protein -
MUA75_RS01540 (MUA75_01535) 346198..346887 + 690 WP_252549763.1 N-6 DNA methylase -
MUA75_RS01545 (MUA75_01540) 346901..347107 + 207 WP_252549760.1 hypothetical protein -
MUA75_RS01550 (MUA75_01545) 347135..347536 + 402 WP_252549758.1 hypothetical protein -
MUA75_RS01555 (MUA75_01550) 347533..347880 + 348 WP_252570428.1 YopX family protein -
MUA75_RS01560 (MUA75_01555) 347877..348098 + 222 Protein_309 hypothetical protein -
MUA75_RS01565 (MUA75_01560) 348178..348429 + 252 WP_110166336.1 DUF1024 family protein Toxin
MUA75_RS01570 (MUA75_01565) 348419..348592 + 174 WP_000028424.1 hypothetical protein Antitoxin
MUA75_RS01575 (MUA75_01570) 348593..348874 + 282 WP_000454994.1 hypothetical protein -
MUA75_RS01580 (MUA75_01575) 348875..349036 + 162 WP_000889683.1 hypothetical protein -
MUA75_RS01585 (MUA75_01580) 349051..349584 + 534 WP_025920701.1 dUTP diphosphatase -
MUA75_RS01590 (MUA75_01585) 349621..349827 + 207 WP_033859700.1 DUF1381 domain-containing protein -
MUA75_RS01595 (MUA75_01590) 349824..349973 + 150 WP_000595265.1 transcriptional activator RinB -
MUA75_RS01600 (MUA75_01595) 349973..350173 + 201 WP_111761860.1 DUF1514 family protein -
MUA75_RS01605 (MUA75_01600) 350196..350657 + 462 WP_086037675.1 hypothetical protein -
MUA75_RS01610 (MUA75_01605) 350772..351224 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
MUA75_RS01615 (MUA75_01610) 351240..351584 + 345 WP_000817289.1 HNH endonuclease -
MUA75_RS01620 (MUA75_01615) 351713..352183 + 471 WP_262629987.1 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 332510..373942 41432


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9445.35 Da        Isoelectric Point: 3.9476

>T240474 WP_110166336.1 NZ_CP094795:348178-348429 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T240474 NZ_LT222314:c41634-41362 [Pseudomonas cerasi]
GTGCTAGTTGAGTGGCTTCCACAAGCTTTGGAGGCACTGGAGGAAATCGCCGGCTACCTAGCCGAGCGCAACCCTTATGC
TGCCGAGCAGATGCAGGCCACCCTTGAGGCCACGGTCGAGGCTCTCCCCCTGCACCCTTACATCCACCGTCCCGGCCGTG
TTCCAGGAACGCGCGAAGCGGTTGTGCATCCCAACTACCTGGTTGTCTACCGCGTCGGTACAGAGCGCATCAGCATCTTG
GACGTCCTGCACGCCCGCCAAGAGTACCCCTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT240474 WP_000028424.1 NZ_CP094795:348419-348592 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT240474 NZ_LT222314:c41809-41624 [Pseudomonas cerasi]
ATGAGCATTCAACTTGACCCTCGCGTCTCGGAGTTCGAGACCCAGGAACAGGCCGACAATTACGACCGTTGGTTTCGCCA
GCGTATCGAGCACAGTTTGGCCGATCCGCGTCCACCCGTGCCGCACGATGAAGCAATGGCTCGCGTCAGAGCCATGATCG
AAGCAAAGCGCCGCCGTGCTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References