Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2505724..2506247 Replicon chromosome
Accession NZ_CP094793
Organism Staphylococcus aureus strain IVB6165

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MUA93_RS12420 Protein ID WP_000074048.1
Coordinates 2505724..2505990 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA93_RS12425 Protein ID WP_252549875.1
Coordinates 2505990..2506247 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA93_RS12400 (MUA93_12385) 2500943..2502130 - 1188 WP_000026189.1 MFS transporter -
MUA93_RS12405 (MUA93_12390) 2502525..2503301 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
MUA93_RS12410 (MUA93_12395) 2503294..2503956 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
MUA93_RS12415 (MUA93_12400) 2504301..2505368 - 1068 WP_001076685.1 M42 family metallopeptidase -
MUA93_RS12420 (MUA93_12405) 2505724..2505990 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MUA93_RS12425 (MUA93_12410) 2505990..2506247 - 258 WP_252549875.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA93_RS12430 (MUA93_12415) 2506607..2507062 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MUA93_RS12435 (MUA93_12420) 2507230..2508807 - 1578 WP_000143506.1 FMN-binding glutamate synthase family protein -
MUA93_RS12440 (MUA93_12425) 2509001..2509750 + 750 WP_000072456.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA93_RS12445 (MUA93_12430) 2509974..2511167 - 1194 WP_252549877.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240473 WP_000074048.1 NZ_CP094793:c2505990-2505724 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240473 NZ_LT222313:c76939-76640 [Pseudomonas cerasi]
ATGACGACGATAAAACAGACCTCTACCTATATGGCTTGGGAACGCAGGCTTAAAGACCAGAAGGCCAAAGCTGCAATTGC
CGCTCGTATTTTTAGAGTTGCAAATGGCCTGATGGGTGATGTCTCTCCAGTAGGACAGGGCGTTAGTGAGCTACGGATAC
ACGTTGGCCCTGGTTACCGTGTTTATTTCCAGCAGCGAGGCGATGAACTGATCTTGCTGCTGTGCGGTGGTGACAAGAGC
AGCCAATCCCGAGATATCGAAACAGCCAAGAAACTGGCTGATCAATGGTGGCAAGAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9748.69 Da        Isoelectric Point: 4.0717

>AT240473 WP_252549875.1 NZ_CP094793:c2506247-2505990 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNDNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240473 NZ_LT222313:c76643-76359 [Pseudomonas cerasi]
ATGAAAGAACAAATTTTCGATTACGACCCAGCAGCAGCCCTTGACGGTCCTGAAGCAATCGCGATTTTTATCTCTGATGC
CTTTGAGACGGGGGATGCGGAGTACATCGCGAAGGCTATGGGGGTTGTCGCAAGGGCCAAAGGGATGACCGAGCTTGCGC
GCGAGACAGGTCTGTCTCGAGAGCAGCTTTATCGGTCGTTCAGTAGCAAGGGCAATCCAACCTTAAAAACCATGTTGACG
GTAATGAGAGCCCTGGGCGTGGATATGACAGCTCGAATGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure

References