Detailed information of TA system TA240471

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2474417..2474601
• Replicon: chromosome
• Accession: NZ_CP094793
• Organism: Staphylococcus aureus strain IVB6165

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA93_RS12275
• Protein ID: WP_000482647.1
• Coordinates: 2474494..2474601 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2474417..2474477 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA93_RS12260 (MUA93_12250)	2469871..2470038	-	168	WP_031927726.1	hypothetical protein	-
MUA93_RS12265 (MUA93_12255)	2470269..2472002	-	1734	WP_000486497.1	ABC transporter ATP-binding protein	-
MUA93_RS12270 (MUA93_12260)	2472027..2473790	-	1764	WP_252549861.1	ABC transporter ATP-binding protein	-
-	2474417..2474477	+	61	-	-	Antitoxin
MUA93_RS12275 (MUA93_12265)	2474494..2474601	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA93_RS12280 (MUA93_12270)	2474735..2475121	-	387	WP_000779353.1	flippase GtxA	-
MUA93_RS12285 (MUA93_12275)	2475389..2476531	+	1143	WP_001176867.1	glycerate kinase	-
MUA93_RS12290 (MUA93_12280)	2476591..2477250	+	660	WP_000831298.1	membrane protein	-
MUA93_RS12295 (MUA93_12285)	2477433..2478644	+	1212	WP_001191927.1	multidrug effflux MFS transporter	-
MUA93_RS12300 (MUA93_12290)	2478767..2479240	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240471 WP_000482647.1 NZ_CP094793:c2474601-2474494 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240471 NZ_LT222313:c35220-34870 [Pseudomonas cerasi]
ATGAATACGTTTGCACTACGCTTTACCGAGGTTGCCCAGCAAAGCATTGAAGATCAGGTCGAGCACCTGGCTATCACTCA
GGGATTCTCATCAGCTGCTCAGCGCATAGATACCCTGATCGATGCCATCCAGGACAAGCTCCTGTCCACCCCTTTGGGCT
ACCCGGTCAGTCCACAGTTGAGTGAGCTGGGTGTACTGCACTATCGTGAGTTGAACACTGACGGATACCGGATCTTTTAT
GAGGTGATGGATTCTGATGGTATTACCGATATCGCCGTATTGCTCGTATTAGGCGGGAAACAAAGTGTGGAGCAGGCTCT
GATCCGCTACTGCCTGCTCCAGCCGATGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT240471 NZ_CP094793:2474417-2474477 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin