Detailed information of TA system TA240463

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1581689..1582268
• Replicon: chromosome
• Accession: NZ_CP094793
• Organism: Staphylococcus aureus strain IVB6165

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MUA93_RS07610
• Protein ID: WP_001025401.1
• Coordinates: 1582023..1582268 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1581689..1582054 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA93_RS07570 (MUA93_07560)	1578431..1578988	-	558	WP_000645049.1	DUF2815 family protein	-
MUA93_RS07575 (MUA93_07565)	1579015..1580181	-	1167	WP_233665663.1	DUF2800 domain-containing protein	-
MUA93_RS07580 (MUA93_07570)	1580178..1580540	-	363	WP_000985986.1	hypothetical protein	-
MUA93_RS07585 (MUA93_07575)	1580555..1580878	-	324	WP_000175000.1	hypothetical protein	-
MUA93_RS07590 (MUA93_07580)	1580957..1581118	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
MUA93_RS07595 (MUA93_07585)	1581131..1581394	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
MUA93_RS07600 (MUA93_07590)	1581419..1581634	-	216	WP_001097552.1	hypothetical protein	-
MUA93_RS07605 (MUA93_07595)	1581689..1582054	+	366	WP_001128433.1	hypothetical protein	Antitoxin
MUA93_RS07610 (MUA93_07600)	1582023..1582268	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MUA93_RS07615 (MUA93_07605)	1582284..1582532	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
MUA93_RS07620 (MUA93_07610)	1582696..1583019	+	324	WP_001260486.1	helix-turn-helix transcriptional regulator	-
MUA93_RS07625 (MUA93_07615)	1583032..1583493	+	462	WP_262541840.1	toxin	-
MUA93_RS07630 (MUA93_07620)	1583511..1583945	+	435	WP_031903825.1	hypothetical protein	-
MUA93_RS07635 (MUA93_07625)	1583973..1584368	+	396	WP_001558060.1	hypothetical protein	-
MUA93_RS07640 (MUA93_07630)	1584476..1584667	+	192	WP_252559444.1	hypothetical protein	-
MUA93_RS07645 (MUA93_07635)	1584664..1584951	-	288	WP_258415362.1	hypothetical protein	-
MUA93_RS07650 (MUA93_07640)	1585368..1586573	+	1206	WP_000264747.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1538900..1604204	65304

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T240463 WP_001025401.1 NZ_CP094793:c1582268-1582023 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T240463 NZ_LT009690:c2515285-2515178 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT240463 NZ_CP094793:1581689-1582054 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin