Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2576430..2576947 Replicon chromosome
Accession NZ_CP094791
Organism Staphylococcus aureus strain IVB6166

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag MUA80_RS13100 Protein ID WP_000251928.1
Coordinates 2576430..2576696 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag MUA80_RS13105 Protein ID WP_000584497.1
Coordinates 2576696..2576947 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA80_RS13075 (MUA80_13050) 2571637..2572173 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
MUA80_RS13080 (MUA80_13055) 2572641..2573465 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA80_RS13085 (MUA80_13060) 2573668..2573850 - 183 WP_000079140.1 hypothetical protein -
MUA80_RS13090 (MUA80_13065) 2573937..2574404 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA80_RS13095 (MUA80_13070) 2574590..2576137 - 1548 WP_045179540.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA80_RS13100 (MUA80_13075) 2576430..2576696 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
MUA80_RS13105 (MUA80_13080) 2576696..2576947 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA80_RS13110 (MUA80_13085) 2577111..2577211 - 101 Protein_2540 hypothetical protein -
MUA80_RS13115 (MUA80_13090) 2577218..2577817 - 600 WP_000162804.1 DsbA family protein -
MUA80_RS13120 (MUA80_13095) 2577836..2578198 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA80_RS13125 (MUA80_13100) 2578453..2579703 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
MUA80_RS13130 (MUA80_13105) 2579800..2580531 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
MUA80_RS13135 (MUA80_13110) 2580528..2581247 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T240457 WP_000251928.1 NZ_CP094791:c2576696-2576430 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240457 NZ_LT009690:c1944909-1944757 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT240457 WP_000584497.1 NZ_CP094791:c2576947-2576696 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT240457 NZ_LT009690:c1945533-1944934 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References