240450

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2022866..2023046 Replicon chromosome
Accession NZ_CP094791
Organism Staphylococcus aureus strain IVB6166

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag MUA80_RS10110 Protein ID WP_001801861.1
Coordinates 2022866..2022961 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2022989..2023046 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA80_RS10080 (MUA80_10060) 2018010..2018636 + 627 WP_000669038.1 hypothetical protein -
MUA80_RS10085 (MUA80_10065) 2018677..2019021 + 345 WP_000627550.1 DUF3969 family protein -
MUA80_RS10090 (MUA80_10070) 2019119..2019691 + 573 WP_000414222.1 hypothetical protein -
MUA80_RS10095 (MUA80_10075) 2019840..2021207 - 1368 WP_001093574.1 FRG domain-containing protein -
MUA80_RS10100 (MUA80_10080) 2021207..2021776 - 570 WP_000125075.1 ImmA/IrrE family metallo-endopeptidase -
MUA80_RS10105 (MUA80_10085) 2021969..2022415 - 447 WP_000747804.1 DUF1433 domain-containing protein -
MUA80_RS10110 (MUA80_10090) 2022866..2022961 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2022989..2023046 - 58 - - Antitoxin
MUA80_RS10115 (MUA80_10095) 2023084..2023185 + 102 WP_001791232.1 hypothetical protein -
MUA80_RS10120 (MUA80_10100) 2023360..2023802 - 443 Protein_1994 DUF1433 domain-containing protein -
MUA80_RS10125 (MUA80_10105) 2023802..2024245 - 444 WP_000731421.1 DUF1433 domain-containing protein -
MUA80_RS10130 (MUA80_10110) 2024245..2024687 - 443 Protein_1996 DUF1433 domain-containing protein -
MUA80_RS10135 (MUA80_10115) 2025213..2027633 + 2421 WP_045179297.1 polysaccharide lyase 8 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T240450 WP_001801861.1 NZ_CP094791:2022866-2022961 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T240450 NZ_LS999562:73802-73954 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 58 bp

>AT240450 NZ_CP094791:c2023046-2022989 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References