Detailed information of TA system TA240446

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1657483..1657774
• Replicon: chromosome
• Accession: NZ_CP094791
• Organism: Staphylococcus aureus strain IVB6166

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MUA80_RS08170
• Protein ID: WP_078061146.1
• Coordinates: 1657598..1657774 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1657483..1657539 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA80_RS08140 (MUA80_08120)	1653657..1654565	-	909	WP_045178743.1	DUF1672 domain-containing protein	-
MUA80_RS08145 (MUA80_08125)	1654655..1654870	-	216	WP_045178742.1	hypothetical protein	-
MUA80_RS08150 (MUA80_08130)	1655692..1656183	-	492	WP_045178740.1	staphylokinase	-
MUA80_RS08155 (MUA80_08135)	1656373..1657128	-	756	WP_045178739.1	CHAP domain-containing protein	-
MUA80_RS08160 (MUA80_08140)	1657140..1657394	-	255	WP_045178738.1	phage holin	-
MUA80_RS08165 (MUA80_08145)	1657446..1657546	+	101	Protein_1604	hypothetical protein	-
-	1657483..1657539	+	57	-	-	Antitoxin
MUA80_RS08170 (MUA80_08150)	1657598..1657774	-	177	WP_078061146.1	type I toxin-antitoxin system toxin PepG1	Toxin
MUA80_RS08175 (MUA80_08155)	1657975..1658700	-	726	Protein_1606	exotoxin	-
MUA80_RS08180 (MUA80_08160)	1658719..1660365	-	1647	WP_000277741.1	IS1182-like element ISSau3 family transposase	-
MUA80_RS08185 (MUA80_08165)	1661125..1661493	-	369	WP_135831022.1	hypothetical protein	-
MUA80_RS08190 (MUA80_08170)	1661588..1661875	-	288	WP_001040260.1	hypothetical protein	-
MUA80_RS08195 (MUA80_08175)	1661922..1662074	-	153	WP_001153680.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / sea	1653657..1711998	58341
	-	flank	IS/Tn	-	-	1658719..1660365	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6848.50 Da
• Isoelectric Point: 10.6777

>T240446 WP_078061146.1 NZ_CP094791:c1657774-1657598 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSIKK

Nucleotide

• Length: 177 bp

>T240446 NZ_LS999561:c42829-42413 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT240446 NZ_CP094791:1657483-1657539 [Staphylococcus aureus]
AAAAGGGCAACATGCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin