Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2633045..2633568 Replicon chromosome
Accession NZ_CP094789
Organism Staphylococcus aureus strain IVB6167

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag MUA09_RS13370 Protein ID WP_000074047.1
Coordinates 2633045..2633311 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag MUA09_RS13375 Protein ID WP_000587617.1
Coordinates 2633311..2633568 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA09_RS13350 (MUA09_13330) 2628255..2629442 - 1188 WP_000026190.1 MFS transporter -
MUA09_RS13355 (MUA09_13335) 2629836..2630612 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
MUA09_RS13360 (MUA09_13340) 2630605..2631267 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
MUA09_RS13365 (MUA09_13345) 2631613..2632689 - 1077 WP_001076679.1 M42 family metallopeptidase -
MUA09_RS13370 (MUA09_13350) 2633045..2633311 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
MUA09_RS13375 (MUA09_13355) 2633311..2633568 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA09_RS13380 (MUA09_13360) 2633928..2634383 + 456 WP_000732090.1 YehR family lipoprotein -
MUA09_RS13385 (MUA09_13365) 2634551..2636128 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
MUA09_RS13390 (MUA09_13370) 2636324..2637073 + 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA09_RS13395 (MUA09_13375) 2637297..2638490 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T240442 WP_000074047.1 NZ_CP094789:c2633311-2633045 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240442 NZ_LS999560:c4296290-4295913 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT240442 WP_000587617.1 NZ_CP094789:c2633568-2633311 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240442 NZ_LS999560:c4296748-4296380 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References