Detailed information of TA system TA240440

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2601729..2601913
• Replicon: chromosome
• Accession: NZ_CP094789
• Organism: Staphylococcus aureus strain IVB6167

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA09_RS13230
• Protein ID: WP_000482647.1
• Coordinates: 2601806..2601913 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2601729..2601789 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA09_RS13215 (MUA09_13195)	2597239..2597406	-	168	Protein_2561	hypothetical protein	-
MUA09_RS13220 (MUA09_13200)	2597637..2599370	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
MUA09_RS13225 (MUA09_13205)	2599395..2601158	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	2601729..2601789	+	61	-	-	Antitoxin
MUA09_RS13230 (MUA09_13210)	2601806..2601913	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA09_RS13235 (MUA09_13215)	2602047..2602433	-	387	WP_000779351.1	flippase GtxA	-
MUA09_RS13240 (MUA09_13220)	2602701..2603843	+	1143	WP_001176855.1	glycerate kinase	-
MUA09_RS13245 (MUA09_13225)	2603903..2604562	+	660	WP_000831298.1	membrane protein	-
MUA09_RS13250 (MUA09_13230)	2604744..2605955	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
MUA09_RS13255 (MUA09_13235)	2606078..2606551	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240440 WP_000482647.1 NZ_CP094789:c2601913-2601806 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240440 NZ_LS999560:c4214430-4214143 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240440 NZ_CP094789:2601729-2601789 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin