Detailed information of TA system TA240432

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2022866..2023046
• Replicon: chromosome
• Accession: NZ_CP094789
• Organism: Staphylococcus aureus strain IVB6167

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA09_RS10110
• Protein ID: WP_001801861.1
• Coordinates: 2022866..2022961 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2022989..2023046 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA09_RS10080 (MUA09_10060)	2018010..2018636	+	627	WP_000669038.1	hypothetical protein	-
MUA09_RS10085 (MUA09_10065)	2018677..2019021	+	345	WP_000627550.1	DUF3969 family protein	-
MUA09_RS10090 (MUA09_10070)	2019119..2019691	+	573	WP_000414222.1	hypothetical protein	-
MUA09_RS10095 (MUA09_10075)	2019840..2021207	-	1368	WP_001093574.1	FRG domain-containing protein	-
MUA09_RS10100 (MUA09_10080)	2021207..2021776	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
MUA09_RS10105 (MUA09_10085)	2021969..2022415	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
MUA09_RS10110 (MUA09_10090)	2022866..2022961	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2022989..2023046	-	58	-	-	Antitoxin
MUA09_RS10115 (MUA09_10095)	2023084..2023185	+	102	WP_001791232.1	hypothetical protein	-
MUA09_RS10120 (MUA09_10100)	2023360..2023802	-	443	Protein_1994	DUF1433 domain-containing protein	-
MUA09_RS10125 (MUA09_10105)	2023802..2024245	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
MUA09_RS10130 (MUA09_10110)	2024245..2024687	-	443	Protein_1996	DUF1433 domain-containing protein	-
MUA09_RS10135 (MUA09_10115)	2025213..2027633	+	2421	WP_045179297.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240432 WP_001801861.1 NZ_CP094789:2022866-2022961 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240432 NZ_LS999560:c1897207-1896833 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240432 NZ_CP094789:c2023046-2022989 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin