Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2485036..2485559 Replicon chromosome
Accession NZ_CP094787
Organism Staphylococcus aureus strain IVB6168

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MUA13_RS12300 Protein ID WP_000074048.1
Coordinates 2485036..2485302 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MUA13_RS12305 Protein ID WP_000587616.1
Coordinates 2485302..2485559 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA13_RS12280 (MUA13_12270) 2480342..2481529 - 1188 WP_000026189.1 MFS transporter -
MUA13_RS12285 (MUA13_12275) 2481925..2482701 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
MUA13_RS12290 (MUA13_12280) 2482694..2483356 - 663 WP_252570656.1 ATP-binding cassette domain-containing protein -
MUA13_RS12295 (MUA13_12285) 2483604..2484680 - 1077 WP_001076671.1 M42 family metallopeptidase -
MUA13_RS12300 (MUA13_12290) 2485036..2485302 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MUA13_RS12305 (MUA13_12295) 2485302..2485559 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA13_RS12310 (MUA13_12300) 2485918..2486373 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MUA13_RS12315 (MUA13_12305) 2486541..2488118 - 1578 WP_252570655.1 FMN-binding glutamate synthase family protein -
MUA13_RS12320 (MUA13_12310) 2488313..2489062 + 750 WP_000072441.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA13_RS12325 (MUA13_12315) 2489286..2490479 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240424 WP_000074048.1 NZ_CP094787:c2485302-2485036 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240424 NZ_LS999560:185249-185356 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT240424 WP_000587616.1 NZ_CP094787:c2485559-2485302 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240424 NZ_LS999560:c185192-185135 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References