Detailed information of TA system TA240422

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2452566..2452750
• Replicon: chromosome
• Accession: NZ_CP094787
• Organism: Staphylococcus aureus strain IVB6168

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA13_RS12155
• Protein ID: WP_000482647.1
• Coordinates: 2452643..2452750 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2452566..2452626 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA13_RS12140 (MUA13_12130)	2448026..2448193	-	168	WP_041204334.1	hypothetical protein	-
MUA13_RS12145 (MUA13_12135)	2448424..2450157	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MUA13_RS12150 (MUA13_12140)	2450182..2451939	-	1758	Protein_2347	ABC transporter ATP-binding protein/permease	-
-	2452566..2452626	+	61	-	-	Antitoxin
MUA13_RS12155 (MUA13_12145)	2452643..2452750	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA13_RS12160 (MUA13_12150)	2452884..2453270	-	387	WP_000779347.1	flippase GtxA	-
MUA13_RS12165 (MUA13_12155)	2453528..2454670	+	1143	WP_001176863.1	glycerate kinase	-
MUA13_RS12170 (MUA13_12160)	2454730..2455389	+	660	WP_000831298.1	membrane protein	-
MUA13_RS12175 (MUA13_12165)	2455571..2456782	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MUA13_RS12180 (MUA13_12170)	2456905..2457378	-	474	WP_262522446.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240422 WP_000482647.1 NZ_CP094787:c2452750-2452643 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240422 NZ_LS999521:478231-478620 [Acinetobacter calcoaceticus]
TTGATAAAAGAATTGAATTTTGAGCTGAAATATAGTCGTTTCTCGATAATATTTCAGCTTTTTATTGGCTTGAGTTTAAC
AATCCTACTTTATCAATTGTTATCACCAATTTGGTGGTTGATTGCTCTCATTCTTTTGTCTATTAGTTTTCTATTTTTTT
TGAAACAATCACGAATTTCTCAAATTGCATATTTAGACCAAAAATTGTGGTCAGTTGCATACTCTTCGCAAAAGATAATT
TCCCGTATAGAAATCACTAAAATAATTGATTATCAGTTATTTATTGTTATTTATTTTGAAGGGGCACCAATAAAAGTAGC
TATAATTTGGTTTGATCAACTTCCTTTACAGGATTGGAAAAAATTAAAAATCTTACAGAAAGTTTATTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240422 NZ_CP094787:2452566-2452626 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCTATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin