240421

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2427154..2427671 Replicon chromosome
Accession NZ_CP094787
Organism Staphylococcus aureus strain IVB6168

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA13_RS12020 Protein ID WP_252569207.1
Coordinates 2427154..2427420 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA13_RS12025 Protein ID WP_061838810.1
Coordinates 2427420..2427671 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA13_RS11990 (MUA13_11980) 2422574..2423110 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MUA13_RS11995 (MUA13_11985) 2423344..2424168 - 825 WP_000572040.1 formate/nitrite transporter family protein -
MUA13_RS12000 (MUA13_11990) 2424385..2424567 - 183 WP_000079140.1 hypothetical protein -
MUA13_RS12005 (MUA13_11995) 2424654..2425121 - 468 WP_000153344.1 SRPBCC domain-containing protein -
MUA13_RS12010 (MUA13_12000) 2425307..2426860 - 1554 WP_262522443.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA13_RS12015 (MUA13_12005) 2427048..2427119 - 72 WP_223200558.1 hypothetical protein -
MUA13_RS12020 (MUA13_12010) 2427154..2427420 - 267 WP_252569207.1 Txe/YoeB family addiction module toxin Toxin
MUA13_RS12025 (MUA13_12015) 2427420..2427671 - 252 WP_061838810.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA13_RS12030 (MUA13_12020) 2427836..2427916 - 81 WP_223197974.1 hypothetical protein -
MUA13_RS12035 (MUA13_12025) 2427944..2428543 - 600 WP_252569210.1 DsbA family protein -
MUA13_RS12040 (MUA13_12030) 2428562..2428924 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA13_RS12045 (MUA13_12035) 2429256..2430417 + 1162 Protein_2326 aminoacyltransferase -
MUA13_RS12050 (MUA13_12040) 2430514..2431245 - 732 WP_168768629.1 amino acid ABC transporter ATP-binding protein -
MUA13_RS12055 (MUA13_12045) 2431242..2431961 - 720 WP_252569213.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10351.94 Da        Isoelectric Point: 10.1415

>T240421 WP_252569207.1 NZ_CP094787:c2427420-2427154 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQKDKKMVKKINELLKSIDGNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240421 NZ_LS999207:9608-9769 [Enterobacter hormaechei]
ATGAAACTGCCGCGAAACGCCCTTATCTGGTGCGTATTAATCGTGTGTTTAACGCTCTTAATATTCACATGCCTGACCCG
GAACCGCTTATGCGAACTCCGGCTAAAGGACGGGGACAGGGAGGTCGCGGCAAGCCTGGCTTACGAATCCAACGGTAAGT
AG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.63 Da        Isoelectric Point: 4.3407

>AT240421 WP_061838810.1 NZ_CP094787:c2427671-2427420 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSITDLERGKTITKD
IDV

Download         Length: 252 bp

>AT240421 NZ_LS999207:9440-9563 [Enterobacter hormaechei]
GGCGCTTGAGGCTTTTTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGCAGAAAGCCCCGTAGT
TAATTTTCATTAACCCACGAGGCCCACTGAATGTCTAGTCAACA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References