Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 343021..343435 Replicon chromosome
Accession NZ_CP094787
Organism Staphylococcus aureus strain IVB6168

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA13_RS01550 Protein ID WP_200706485.1
Coordinates 343021..343272 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA13_RS01555 Protein ID WP_000028424.1
Coordinates 343262..343435 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA13_RS01480 (MUA13_01480) 338187..338972 + 786 WP_000443353.1 ATP-binding protein -
MUA13_RS01485 (MUA13_01485) 338969..339127 + 159 WP_000628833.1 hypothetical protein -
MUA13_RS01490 (MUA13_01490) 339140..339361 + 222 WP_001123695.1 DUF3269 family protein -
MUA13_RS01495 (MUA13_01495) 339372..339776 + 405 WP_000049784.1 DUF1064 domain-containing protein -
MUA13_RS01500 (MUA13_01500) 339781..339966 + 186 WP_001187242.1 DUF3113 family protein -
MUA13_RS01505 (MUA13_01505) 339967..340293 + 327 WP_252570421.1 hypothetical protein -
MUA13_RS01510 (MUA13_01510) 340294..340584 + 291 WP_252570423.1 SA1788 family PVL leukocidin-associated protein -
MUA13_RS01515 (MUA13_01515) 340584..340841 + 258 WP_031864864.1 DUF3310 domain-containing protein -
MUA13_RS01520 (MUA13_01520) 340844..341044 + 201 WP_252549766.1 hypothetical protein -
MUA13_RS01525 (MUA13_01525) 341041..341730 + 690 WP_252549763.1 N-6 DNA methylase -
MUA13_RS01530 (MUA13_01530) 341744..341950 + 207 WP_252549760.1 hypothetical protein -
MUA13_RS01535 (MUA13_01535) 341978..342379 + 402 WP_252549758.1 hypothetical protein -
MUA13_RS01540 (MUA13_01540) 342376..342723 + 348 WP_252570428.1 YopX family protein -
MUA13_RS01545 (MUA13_01545) 342720..342941 + 222 Protein_306 hypothetical protein -
MUA13_RS01550 (MUA13_01550) 343021..343272 + 252 WP_200706485.1 DUF1024 family protein Toxin
MUA13_RS01555 (MUA13_01555) 343262..343435 + 174 WP_000028424.1 hypothetical protein Antitoxin
MUA13_RS01560 (MUA13_01560) 343436..343717 + 282 WP_000454994.1 hypothetical protein -
MUA13_RS01565 (MUA13_01565) 343718..343879 + 162 WP_000889683.1 hypothetical protein -
MUA13_RS01570 (MUA13_01570) 343894..344427 + 534 WP_025920701.1 dUTP diphosphatase -
MUA13_RS01575 (MUA13_01575) 344464..344670 + 207 WP_033859700.1 DUF1381 domain-containing protein -
MUA13_RS01580 (MUA13_01580) 344667..344816 + 150 WP_000595265.1 transcriptional activator RinB -
MUA13_RS01585 (MUA13_01585) 344816..345016 + 201 WP_111761860.1 DUF1514 family protein -
MUA13_RS01590 (MUA13_01590) 345039..345500 + 462 WP_000282752.1 hypothetical protein -
MUA13_RS01595 (MUA13_01595) 345614..346066 + 453 WP_000406193.1 nucleoside triphosphate pyrophosphohydrolase family protein -
MUA13_RS01600 (MUA13_01600) 346082..346426 + 345 WP_016169209.1 HNH endonuclease -
MUA13_RS01605 (MUA13_01605) 346555..347022 + 468 WP_000919027.1 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 327353..368811 41458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9404.25 Da        Isoelectric Point: 3.8567

>T240415 WP_200706485.1 NZ_CP094787:343021-343272 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKSARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T240415 NZ_LS999206:c2975457-2975203 [Enterobacter hormaechei]
GTGAAGCTGATCTGGTCTGAGCAAGCCTGGGACGATTATCTGTACTGGCAAGAGGCGGATAAGCGTATGGTCAAGAAGCT
CAACGAGCTGATCAAGGAGACCCGCCGCACCCCTTTCGAGGGCAAGGGCAAGCCGGAGCCGCTTCGCCACAACCTGGCGG
GCTTCTGGTCGAGGCGGATCACCGCCGAGCACCGGTTTGTGTATTCGGTGACGGACGAGGCGCTGCTGATTGCCGCCTGC
CGTTATCACTATTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT240415 WP_000028424.1 NZ_CP094787:343262-343435 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT240415 NZ_LS999206:c2975705-2975454 [Enterobacter hormaechei]
ATGCGCACTATCAGCTATACCGAAGCCCGGCAGAACCTGTCGGCCACCATGGTGCAGACCGTCGAGGATCGCGTGCCTAC
CCTCATTACCCGCCAGAACGGCGAGGCGTGCGTGCTGATGTCGCTGGAGGAGTACAACGCGCTGGAGGAAACGGCTTACC
TGCTGCGCTCGCCGGCCAACGCGCGCCGCCTGATGGATTCGATTGACAGCCTCAAGCGTGGCCAGGGTGTCGAGCGGGAT
ATCGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References