Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2576427..2576944 | Replicon | chromosome |
| Accession | NZ_CP094785 | ||
| Organism | Staphylococcus aureus strain IVB6169 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A170NWK0 |
| Locus tag | MUA79_RS13075 | Protein ID | WP_000251928.1 |
| Coordinates | 2576427..2576693 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A166LMC5 |
| Locus tag | MUA79_RS13080 | Protein ID | WP_000584497.1 |
| Coordinates | 2576693..2576944 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA79_RS13050 (MUA79_13035) | 2571634..2572170 | - | 537 | WP_000024292.1 | GNAT family N-acetyltransferase | - |
| MUA79_RS13055 (MUA79_13040) | 2572638..2573462 | - | 825 | WP_000594640.1 | formate/nitrite transporter family protein | - |
| MUA79_RS13060 (MUA79_13045) | 2573665..2573847 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| MUA79_RS13065 (MUA79_13050) | 2573934..2574401 | - | 468 | WP_000153340.1 | SRPBCC domain-containing protein | - |
| MUA79_RS13070 (MUA79_13055) | 2574587..2576134 | - | 1548 | WP_045179540.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MUA79_RS13075 (MUA79_13060) | 2576427..2576693 | - | 267 | WP_000251928.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUA79_RS13080 (MUA79_13065) | 2576693..2576944 | - | 252 | WP_000584497.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUA79_RS13085 (MUA79_13070) | 2577108..2577208 | - | 101 | Protein_2535 | hypothetical protein | - |
| MUA79_RS13090 (MUA79_13075) | 2577215..2577814 | - | 600 | WP_000162804.1 | DsbA family protein | - |
| MUA79_RS13095 (MUA79_13080) | 2577833..2578195 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MUA79_RS13100 (MUA79_13085) | 2578450..2579700 | + | 1251 | WP_001012237.1 | FemA/FemB family glycyltransferase FmhA | - |
| MUA79_RS13105 (MUA79_13090) | 2579797..2580528 | - | 732 | WP_000615467.1 | amino acid ABC transporter ATP-binding protein | - |
| MUA79_RS13110 (MUA79_13095) | 2580525..2581244 | - | 720 | WP_000479573.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10465.06 Da Isoelectric Point: 10.1628
>T240411 WP_000251928.1 NZ_CP094785:c2576693-2576427 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T240411 NZ_LS999206:c1244465-1244154 [Enterobacter hormaechei]
ATGCACATAGTCTCAAGAGCGCCTTTCGACACAGCGGCCAGACATTATCCCAATCAAGCACAAGCCCTGGACGATCTTTA
CCGGGTACTAAAAAAGGAACACTACCCCTCACCAGACGAGATGCGAAAGCGCTTTCCTAGCCTGGACCGGATGAAATACC
GGGAAAAATGGTGGGTCATTGATGTGGGTGGCGGGCATCTAAGAGTGATGTTTTTTGCTGATTTTGAGCGTGGAAAGATC
TTCATCAAACACATCAGCACTCACGCAGACTATGACAAGCTCACGGACTACTACCGGAGAACGAAAGAATGA
ATGCACATAGTCTCAAGAGCGCCTTTCGACACAGCGGCCAGACATTATCCCAATCAAGCACAAGCCCTGGACGATCTTTA
CCGGGTACTAAAAAAGGAACACTACCCCTCACCAGACGAGATGCGAAAGCGCTTTCCTAGCCTGGACCGGATGAAATACC
GGGAAAAATGGTGGGTCATTGATGTGGGTGGCGGGCATCTAAGAGTGATGTTTTTTGCTGATTTTGAGCGTGGAAAGATC
TTCATCAAACACATCAGCACTCACGCAGACTATGACAAGCTCACGGACTACTACCGGAGAACGAAAGAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9401.54 Da Isoelectric Point: 4.3407
>AT240411 WP_000584497.1 NZ_CP094785:c2576944-2576693 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
Download Length: 252 bp
>AT240411 NZ_LS999206:c1244157-1243738 [Enterobacter hormaechei]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAGCTCCCTTTCCTGGGTTCAAGCCCGTCGCGGCA
AGACTACGAGGATGCGCTGGCGCTGGTGGAGTATCTTATCGAGCACGACCCCGATAACCCGCTGGTAGATATGCTCACTG
CCAAAATCGATAAGTATGAAAACGCGTCCCCGGAGTTTGCAGAATTTAACGCGCGTATTGCCAGCATTCCGTCAGGCGTT
GCGTTACTGCGAACGCTAATGGATCAGTACCAGCTCACTCAGAGTGATTTCGAGAACGAGATTGGTAAGAAGTCTCTGGT
AAGTCGGATCCTTAACGGACAGCGCACGTTAACGCTAGATCATATGCGAGCGCTGGCGAAGCGTTTCGGTTTGCCGGTGA
GCGCATTTGTGGGGAACTGA
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAGCTCCCTTTCCTGGGTTCAAGCCCGTCGCGGCA
AGACTACGAGGATGCGCTGGCGCTGGTGGAGTATCTTATCGAGCACGACCCCGATAACCCGCTGGTAGATATGCTCACTG
CCAAAATCGATAAGTATGAAAACGCGTCCCCGGAGTTTGCAGAATTTAACGCGCGTATTGCCAGCATTCCGTCAGGCGTT
GCGTTACTGCGAACGCTAATGGATCAGTACCAGCTCACTCAGAGTGATTTCGAGAACGAGATTGGTAAGAAGTCTCTGGT
AAGTCGGATCCTTAACGGACAGCGCACGTTAACGCTAGATCATATGCGAGCGCTGGCGAAGCGTTTCGGTTTGCCGGTGA
GCGCATTTGTGGGGAACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A170NWK0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A166LMC5 |