Detailed information of TA system TA240404

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2022866..2023046
• Replicon: chromosome
• Accession: NZ_CP094785
• Organism: Staphylococcus aureus strain IVB6169

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA79_RS10095
• Protein ID: WP_001801861.1
• Coordinates: 2022866..2022961 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2022989..2023046 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA79_RS10065 (MUA79_10050)	2018010..2018636	+	627	WP_000669038.1	hypothetical protein	-
MUA79_RS10070 (MUA79_10055)	2018677..2019021	+	345	WP_000627550.1	DUF3969 family protein	-
MUA79_RS10075 (MUA79_10060)	2019119..2019691	+	573	WP_000414222.1	hypothetical protein	-
MUA79_RS10080 (MUA79_10065)	2019840..2021207	-	1368	WP_001093574.1	FRG domain-containing protein	-
MUA79_RS10085 (MUA79_10070)	2021207..2021776	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
MUA79_RS10090 (MUA79_10075)	2021969..2022415	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
MUA79_RS10095 (MUA79_10080)	2022866..2022961	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2022989..2023046	-	58	-	-	Antitoxin
MUA79_RS10100 (MUA79_10085)	2023084..2023185	+	102	WP_001791232.1	hypothetical protein	-
MUA79_RS10105 (MUA79_10090)	2023360..2023802	-	443	Protein_1991	DUF1433 domain-containing protein	-
MUA79_RS10110 (MUA79_10095)	2023802..2024245	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
MUA79_RS10115 (MUA79_10100)	2024245..2024687	-	443	Protein_1993	DUF1433 domain-containing protein	-
MUA79_RS10120 (MUA79_10105)	2025213..2027633	+	2421	WP_045179297.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240404 WP_001801861.1 NZ_CP094785:2022866-2022961 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240404 NZ_LS999205:3009964-3010563 [Pseudomonas protegens CHA0]
ATGAACAGTGAACTTCTCAGTGGCCGCCTCGACTTTCTCCGTGAAGCGGAAAAACTCAAGGACGTGCTGCGCAGCGCCCA
CACCTCCAGCGGCCGCCAGGAAAGCACGGCCGAGCACAGCTGGCGCCTATGCCTGATGGCGCTGCTGTTCGAAGACCAAC
TGGGGGACCTGGACCTGCTGCGGGTGCTGAAACTGTGCATCGTCCACGACCTGGGGGAGGCCATTCACGGCGACATCCCG
GCGGTGGCCCAGGCTGCCCACCCGGACAAGAGCCAGCAGGAGCGCGACGACCTGCAACTGCTGGCCCGAGCCCTGGACGC
CCCGGCCCGCGAGCACCTGCTGGAGCTGTGGGACGAATACGAAGGCGCCGCCAGCAACGAGGCGCGCGCGGTCAAGGCCC
TGGACAAGCTGGAAACCCTGCTGCAACACACCCAGGGCCAGAACCCGGCGGGTTTCGACTACCGCTTCAACCTCGGCTAC
GGCCGCCGCTACACCGACGCCAGCCCGCTGTTCCAAGCCCTGCGCCAGCAGATCGACATCGACACCCAGCGTTGCCTGGA
CGCCCAGGCTCAGGCCGCGGTTCAGCATCGGCTGCGCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240404 NZ_CP094785:c2023046-2022989 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin