Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2483179..2483702 Replicon chromosome
Accession NZ_CP094783
Organism Staphylococcus aureus strain IVB6170

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MUA30_RS12495 Protein ID WP_000074048.1
Coordinates 2483179..2483445 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MUA30_RS12500 Protein ID WP_000587616.1
Coordinates 2483445..2483702 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA30_RS12475 (2478486) 2478486..2479673 - 1188 WP_000026189.1 MFS transporter -
MUA30_RS12480 (2480069) 2480069..2480845 - 777 WP_262610432.1 iron export ABC transporter permease subunit FetB -
MUA30_RS12485 (2480838) 2480838..2481500 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
MUA30_RS12490 (2481747) 2481747..2482823 - 1077 WP_262610434.1 M42 family metallopeptidase -
MUA30_RS12495 (2483179) 2483179..2483445 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MUA30_RS12500 (2483445) 2483445..2483702 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA30_RS12505 (2484061) 2484061..2484516 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MUA30_RS12510 (2484684) 2484684..2486261 - 1578 WP_262610436.1 FMN-binding glutamate synthase family protein -
MUA30_RS12515 (2486457) 2486457..2487206 + 750 WP_000072458.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA30_RS12520 (2487430) 2487430..2488623 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240396 WP_000074048.1 NZ_CP094783:c2483445-2483179 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240396 NZ_LS998786:6066-6224 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT240396 WP_000587616.1 NZ_CP094783:c2483702-2483445 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240396 NZ_LS998786:c6022-5991 [Escherichia coli]
ATGTGGACTAGACATAGGGATGCCTCGTGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References