240395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2426615..2427132 Replicon chromosome
Accession NZ_CP094783
Organism Staphylococcus aureus strain IVB6170

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA30_RS12225 Protein ID WP_262610396.1
Coordinates 2426615..2426881 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA30_RS12230 Protein ID WP_262610397.1
Coordinates 2426881..2427132 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA30_RS12195 (2422038) 2422038..2422574 - 537 WP_262610393.1 GNAT family N-acetyltransferase -
MUA30_RS12200 (2422807) 2422807..2423631 - 825 WP_262610394.1 formate/nitrite transporter family protein -
MUA30_RS12205 (2423848) 2423848..2424030 - 183 WP_000230294.1 hypothetical protein -
MUA30_RS12210 (2424114) 2424114..2424581 - 468 WP_262610395.1 SRPBCC domain-containing protein -
MUA30_RS12215 (2424767) 2424767..2426320 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA30_RS12220 (2426509) 2426509..2426580 - 72 Protein_2361 hypothetical protein -
MUA30_RS12225 (2426615) 2426615..2426881 - 267 WP_262610396.1 Txe/YoeB family addiction module toxin Toxin
MUA30_RS12230 (2426881) 2426881..2427132 - 252 WP_262610397.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA30_RS12235 (2427296) 2427296..2427376 - 81 WP_223197974.1 hypothetical protein -
MUA30_RS12240 (2427404) 2427404..2428003 - 600 WP_000162810.1 DsbA family protein -
MUA30_RS12245 (2428022) 2428022..2428390 - 369 WP_160195056.1 DUF4467 domain-containing protein -
MUA30_RS12250 (2428645) 2428645..2429895 + 1251 Protein_2367 FemA/FemB family glycyltransferase FmhA -
MUA30_RS12255 (2429992) 2429992..2430723 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUA30_RS12260 (2430720) 2430720..2431439 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10419.92 Da        Isoelectric Point: 9.9143

>T240395 WP_262610396.1 NZ_CP094783:c2426881-2426615 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKIVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240395 NZ_LS998785:c4351700-4351152 [Escherichia coli]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9445.66 Da        Isoelectric Point: 4.3407

>AT240395 WP_262610397.1 NZ_CP094783:c2427132-2426881 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKIITKD
IDV

Download         Length: 252 bp

>AT240395 NZ_LS998785:c4352196-4351723 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References