Detailed information of TA system TA240394

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2165185..2165402
• Replicon: chromosome
• Accession: NZ_CP094783
• Organism: Staphylococcus aureus strain IVB6170

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: MUA30_RS10850
• Protein ID: WP_001802298.1
• Coordinates: 2165298..2165402 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2165185..2165240 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA30_RS10825	2161376..2162041	-	666	WP_262610233.1	SDR family oxidoreductase	-
MUA30_RS10830	2162193..2162513	+	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MUA30_RS10835	2162515..2163492	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
MUA30_RS10840	2163758..2164849	+	1092	WP_262610234.1	transcriptional regulator	-
-	2165185..2165240	+	56	-	-	Antitoxin
MUA30_RS10850	2165298..2165402	-	105	WP_001802298.1	hypothetical protein	Toxin
MUA30_RS10855	2165563..2166046	-	484	Protein_2097	recombinase family protein	-
MUA30_RS10860	2166089..2167225	-	1137	Protein_2098	SAP domain-containing protein	-
MUA30_RS10865	2167514..2167606	+	93	WP_262610235.1	hypothetical protein	-
MUA30_RS10870	2167895..2168079	+	185	Protein_2100	exotoxin	-
MUA30_RS10875	2168311..2169168	-	858	WP_262610236.1	HAD family hydrolase	-
MUA30_RS10880	2169236..2170018	-	783	WP_262610238.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T240394 WP_001802298.1 NZ_CP094783:c2165402-2165298 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T240394 NZ_LS998785:c4241435-4241262 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT240394 NZ_CP094783:2165185-2165240 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin