Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1539753..1540167 Replicon chromosome
Accession NZ_CP094783
Organism Staphylococcus aureus strain IVB6170

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA30_RS07465 Protein ID WP_262609845.1
Coordinates 1539916..1540167 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA30_RS07460 Protein ID WP_000028424.1
Coordinates 1539753..1539926 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA30_RS07405 (1536004) 1536004..1536471 - 468 WP_000919026.1 phage terminase small subunit P27 family -
MUA30_RS07410 (1536599) 1536599..1536943 - 345 WP_000817289.1 HNH endonuclease -
MUA30_RS07415 (1536959) 1536959..1537411 - 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
MUA30_RS07420 (1537526) 1537526..1537996 - 471 WP_262609843.1 hypothetical protein -
MUA30_RS07425 (1538019) 1538019..1538219 - 201 WP_045178577.1 DUF1514 family protein -
MUA30_RS07430 (1538219) 1538219..1538368 - 150 WP_000595265.1 transcriptional activator RinB -
MUA30_RS07435 (1538365) 1538365..1538571 - 207 WP_045178575.1 DUF1381 domain-containing protein -
MUA30_RS07440 (1538568) 1538568..1538813 - 246 WP_063815530.1 hypothetical protein -
MUA30_RS07445 (1538830) 1538830..1539003 - 174 WP_001209216.1 hypothetical protein -
MUA30_RS07450 (1539040) 1539040..1539576 - 537 WP_250396255.1 dUTPase -
MUA30_RS07455 (1539591) 1539591..1539752 - 162 WP_000889680.1 hypothetical protein -
MUA30_RS07460 (1539753) 1539753..1539926 - 174 WP_000028424.1 hypothetical protein Antitoxin
MUA30_RS07465 (1539916) 1539916..1540167 - 252 WP_262609845.1 DUF1024 family protein Toxin
MUA30_RS07470 (1540160) 1540160..1540444 - 285 WP_250396252.1 hypothetical protein -
MUA30_RS07475 (1540459) 1540459..1540701 - 243 WP_262609846.1 phi PVL orf 51-like protein -
MUA30_RS07480 (1540705) 1540705..1541062 - 358 Protein_1467 hypothetical protein -
MUA30_RS07485 (1541063) 1541063..1541248 - 186 WP_001187254.1 DUF3113 family protein -
MUA30_RS07490 (1541253) 1541253..1541657 - 405 WP_262609847.1 DUF1064 domain-containing protein -
MUA30_RS07495 (1541668) 1541668..1541889 - 222 WP_086037726.1 DUF3269 family protein -
MUA30_RS07500 (1541892) 1541892..1542107 - 216 WP_262609848.1 hypothetical protein -
MUA30_RS07505 (1542104) 1542104..1543345 - 1242 WP_234720012.1 DnaB helicase C-terminal domain-containing protein -
MUA30_RS07510 (1543342) 1543342..1543698 - 357 WP_001132243.1 hypothetical protein -
MUA30_RS07515 (1543698) 1543698..1544453 - 756 Protein_1474 DnaD domain protein -
MUA30_RS07520 (1544446) 1544446..1545120 - 675 WP_262609849.1 putative HNHc nuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / gnd 1513528..1578061 64533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9474.38 Da        Isoelectric Point: 3.8567

>T240388 WP_262609845.1 NZ_CP094783:c1540167-1539916 [Staphylococcus aureus]
MNNREQIEQSVISANAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMVSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T240388 NZ_LS998785:c1856837-1856463 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT240388 WP_000028424.1 NZ_CP094783:c1539926-1539753 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT240388 NZ_LS998785:c1857295-1856927 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References