Detailed information of TA system TA240380

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 357649..358096
• Replicon: chromosome
• Accession: NZ_CP094783
• Organism: Staphylococcus aureus strain IVB6170

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: MUA30_RS01675
• Protein ID: WP_262610945.1
• Coordinates: 357794..358096 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	357649..357704 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA30_RS01635	352679..352969	+	291	WP_000179860.1	hypothetical protein	-
MUA30_RS01640	352985..354895	+	1911	WP_262610939.1	hypothetical protein	-
MUA30_RS01645	354895..356361	+	1467	WP_262610941.1	BppU family phage baseplate upper protein	-
MUA30_RS01650	356361..356750	+	390	WP_262610943.1	DUF2977 domain-containing protein	-
MUA30_RS01655	356743..356907	+	165	WP_000916021.1	XkdX family protein	-
MUA30_RS01660	356953..357252	+	300	WP_000466774.1	DUF2951 family protein	-
MUA30_RS01665	357405..357563	+	159	WP_262611649.1	putative holin-like toxin	-
-	357573..357714	-	142	NuclAT_0	-	-
-	357573..357714	-	142	NuclAT_0	-	-
-	357573..357714	-	142	NuclAT_0	-	-
-	357573..357714	-	142	NuclAT_0	-	-
MUA30_RS01670	357634..357743	-	110	Protein_331	hypothetical protein	-
-	357649..357704	-	56	-	-	Antitoxin
MUA30_RS01675	357794..358096	+	303	WP_262610945.1	phage holin	Toxin
MUA30_RS01680	358107..359560	+	1454	Protein_333	N-acetylmuramoyl-L-alanine amidase	-
MUA30_RS01685	360656..361042	+	387	WP_228480554.1	hypothetical protein	-
MUA30_RS01690	361172..361360	+	189	WP_262610947.1	hypothetical protein	-
MUA30_RS01695	361602..362429	-	828	WP_000136014.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	314374..359560	45186

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11202.98 Da
• Isoelectric Point: 9.6413

>T240380 WP_262610945.1 NZ_CP094783:357794-358096 [Staphylococcus aureus]
MDAKVITRYIVLILALVNQFLANKGISPIPVDDETISSIILTVVALYTTYKDNPTSQEGKWANQKLKKYKAENKYRKATG
QVPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T240380 NZ_CP094783:357794-358096 [Staphylococcus aureus]
ATGGATGCAAAAGTAATAACAAGATACATCGTATTGATCTTAGCATTAGTAAATCAATTCTTAGCGAACAAAGGTATTAG
CCCGATTCCAGTAGACGATGAAACTATATCATCAATAATACTTACTGTTGTTGCTTTATATACTACGTATAAAGACAATC
CAACATCTCAAGAAGGTAAATGGGCAAATCAAAAGCTAAAGAAATATAAAGCTGAAAACAAGTATAGAAAAGCAACAGGG
CAAGTGCCAATTAAAGAAGTAATGACACCTACGAATATGAACGACACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT240380 NZ_CP094783:c357704-357649 [Staphylococcus aureus]
AAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin