Detailed information of TA system TA240377

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 357405..357745
• Replicon: chromosome
• Accession: NZ_CP094783
• Organism: Staphylococcus aureus strain IVB6170

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MUA30_RS01665
• Protein ID: WP_262611649.1
• Coordinates: 357405..357563 (+)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	357569..357745 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA30_RS01635	352679..352969	+	291	WP_000179860.1	hypothetical protein	-
MUA30_RS01640	352985..354895	+	1911	WP_262610939.1	hypothetical protein	-
MUA30_RS01645	354895..356361	+	1467	WP_262610941.1	BppU family phage baseplate upper protein	-
MUA30_RS01650	356361..356750	+	390	WP_262610943.1	DUF2977 domain-containing protein	-
MUA30_RS01655	356743..356907	+	165	WP_000916021.1	XkdX family protein	-
MUA30_RS01660	356953..357252	+	300	WP_000466774.1	DUF2951 family protein	-
MUA30_RS01665	357405..357563	+	159	WP_262611649.1	putative holin-like toxin	Toxin
-	357569..357745	-	177	-	-	Antitoxin
MUA30_RS01675	357794..358096	+	303	WP_262610945.1	phage holin	-
MUA30_RS01680	358107..359560	+	1454	Protein_333	N-acetylmuramoyl-L-alanine amidase	-
MUA30_RS01685	360656..361042	+	387	WP_228480554.1	hypothetical protein	-
MUA30_RS01690	361172..361360	+	189	WP_262610947.1	hypothetical protein	-
MUA30_RS01695	361602..362429	-	828	WP_000136014.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	314374..359560	45186

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6163.67 Da
• Isoelectric Point: 10.6140

>T240377 WP_262611649.1 NZ_CP094783:357405-357563 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLI

Nucleotide

• Length: 159 bp

>T240377 NZ_LS998783:c5019140-5018385 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Nucleotide

• Length: 177 bp

>AT240377 NZ_CP094783:c357745-357569 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGC
CCGTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCG
ATGGTTATTTTTTATTG

Structures

Antitoxin