Detailed information of TA system TA240375

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2468322..2468506
• Replicon: chromosome
• Accession: NZ_CP094782
• Organism: Staphylococcus aureus strain IVB6172

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA59_RS12435
• Protein ID: WP_000482647.1
• Coordinates: 2468399..2468506 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2468322..2468382 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA59_RS12420 (MUA59_12390)	2463776..2463943	-	168	WP_001789205.1	hypothetical protein	-
MUA59_RS12425 (MUA59_12395)	2464174..2465907	-	1734	Protein_2405	ABC transporter ATP-binding protein/permease	-
MUA59_RS12430 (MUA59_12400)	2465932..2467695	-	1764	WP_262538151.1	ABC transporter ATP-binding protein	-
-	2468322..2468382	+	61	-	-	Antitoxin
MUA59_RS12435 (MUA59_12405)	2468399..2468506	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA59_RS12440 (MUA59_12410)	2468640..2469026	-	387	WP_000779353.1	flippase GtxA	-
MUA59_RS12445 (MUA59_12415)	2469294..2470436	+	1143	WP_162636418.1	glycerate kinase	-
MUA59_RS12450 (MUA59_12420)	2470496..2471155	+	660	WP_262538147.1	hypothetical protein	-
MUA59_RS12455 (MUA59_12425)	2471337..2472548	+	1212	WP_001191923.1	multidrug effflux MFS transporter	-
MUA59_RS12460 (MUA59_12430)	2472671..2473144	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240375 WP_000482647.1 NZ_CP094782:c2468506-2468399 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240375 NZ_LS998783:3017851-3018426 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTACCCGATCCGAATGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGTGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240375 NZ_CP094782:2468322-2468382 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin