Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2443105..2443622 Replicon chromosome
Accession NZ_CP094782
Organism Staphylococcus aureus strain IVB6172

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag MUA59_RS12300 Protein ID WP_000113263.1
Coordinates 2443105..2443371 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUA59_RS12305 Protein ID WP_000584499.1
Coordinates 2443371..2443622 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA59_RS12275 (MUA59_12245) 2438257..2438793 - 537 WP_262607697.1 GNAT family N-acetyltransferase -
MUA59_RS12280 (MUA59_12250) 2439316..2440140 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA59_RS12285 (MUA59_12255) 2440343..2440525 - 183 WP_000079140.1 hypothetical protein -
MUA59_RS12290 (MUA59_12260) 2440612..2441079 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA59_RS12295 (MUA59_12265) 2441265..2442812 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA59_RS12300 (MUA59_12270) 2443105..2443371 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
MUA59_RS12305 (MUA59_12275) 2443371..2443622 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA59_RS12310 (MUA59_12280) 2443786..2443887 - 102 Protein_2382 hypothetical protein -
MUA59_RS12315 (MUA59_12285) 2443894..2444493 - 600 WP_262607698.1 DsbA family protein -
MUA59_RS12320 (MUA59_12290) 2444512..2444874 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA59_RS12325 (MUA59_12295) 2445129..2446379 + 1251 Protein_2385 FemA/FemB family glycyltransferase FmhA -
MUA59_RS12330 (MUA59_12300) 2446476..2447207 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUA59_RS12335 (MUA59_12305) 2447204..2447923 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T240374 WP_000113263.1 NZ_CP094782:c2443371-2443105 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240374 NZ_LS998783:2719738-2720019 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGTCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGTGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240374 WP_000584499.1 NZ_CP094782:c2443622-2443371 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240374 NZ_LS998783:2719503-2719748 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References