Detailed information of TA system TA240368

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1834312..1834492
• Replicon: chromosome
• Accession: NZ_CP094782
• Organism: Staphylococcus aureus strain IVB6172

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA59_RS08925
• Protein ID: WP_001801861.1
• Coordinates: 1834312..1834407 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1834435..1834492 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA59_RS08895 (MUA59_08875)	1829382..1829954	+	573	WP_000414222.1	hypothetical protein	-
MUA59_RS08900 (MUA59_08880)	1830330..1830929	+	600	WP_262607570.1	ATP-binding cassette domain-containing protein	-
MUA59_RS08905 (MUA59_08885)	1831970..1832155	-	186	WP_000809858.1	hypothetical protein	-
MUA59_RS08910 (MUA59_08890)	1832157..1832333	-	177	WP_000375476.1	hypothetical protein	-
MUA59_RS08915 (MUA59_08895)	1832344..1832727	-	384	WP_000070811.1	hypothetical protein	-
MUA59_RS08920 (MUA59_08900)	1833414..1833860	-	447	WP_000747809.1	DUF1433 domain-containing protein	-
MUA59_RS08925 (MUA59_08905)	1834312..1834407	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1834435..1834492	-	58	-	-	Antitoxin
MUA59_RS08930 (MUA59_08910)	1834530..1834631	+	102	WP_001791232.1	hypothetical protein	-
MUA59_RS08935 (MUA59_08915)	1834669..1834785	-	117	Protein_1760	transposase	-
MUA59_RS08940 (MUA59_08920)	1835293..1839402	-	4110	Protein_1761	SMEK domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240368 WP_001801861.1 NZ_CP094782:1834312-1834407 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240368 NZ_LS998783:c145139-144858 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240368 NZ_CP094782:c1834492-1834435 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin