Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2505718..2506241 Replicon chromosome
Accession NZ_CP094780
Organism Staphylococcus aureus strain IVB6173

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MUA18_RS12395 Protein ID WP_000074048.1
Coordinates 2505718..2505984 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA18_RS12400 Protein ID WP_252549875.1
Coordinates 2505984..2506241 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA18_RS12375 (MUA18_12370) 2500937..2502124 - 1188 WP_000026189.1 MFS transporter -
MUA18_RS12380 (MUA18_12375) 2502519..2503295 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
MUA18_RS12385 (MUA18_12380) 2503288..2503950 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
MUA18_RS12390 (MUA18_12385) 2504295..2505362 - 1068 WP_001076685.1 M42 family metallopeptidase -
MUA18_RS12395 (MUA18_12390) 2505718..2505984 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MUA18_RS12400 (MUA18_12395) 2505984..2506241 - 258 WP_252549875.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA18_RS12405 (MUA18_12400) 2506601..2507056 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MUA18_RS12410 (MUA18_12405) 2507224..2508801 - 1578 WP_000143506.1 FMN-binding glutamate synthase family protein -
MUA18_RS12415 (MUA18_12410) 2508995..2509744 + 750 WP_000072456.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA18_RS12420 (MUA18_12415) 2509968..2511161 - 1194 WP_252549877.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240365 WP_000074048.1 NZ_CP094780:c2505984-2505718 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240365 NZ_LS997868:c604584-604315 [Vibrio cholerae]
ATGTATAAACTCGAATACTCAACACAATTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAGAAGCTTGAACCAAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGTATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9748.69 Da        Isoelectric Point: 4.0717

>AT240365 WP_252549875.1 NZ_CP094780:c2506241-2505984 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNDNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240365 NZ_LS997868:c604855-604577 [Vibrio cholerae]
ATGAGAACAGAAATGCTAAGTACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGTGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAACGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure

References