Detailed information of TA system TA240363

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2474411..2474595
• Replicon: chromosome
• Accession: NZ_CP094780
• Organism: Staphylococcus aureus strain IVB6173

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA18_RS12255
• Protein ID: WP_000482647.1
• Coordinates: 2474488..2474595 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2474411..2474471 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA18_RS12240 (MUA18_12235)	2469865..2470032	-	168	WP_031927726.1	hypothetical protein	-
MUA18_RS12245 (MUA18_12240)	2470263..2471996	-	1734	WP_000486497.1	ABC transporter ATP-binding protein	-
MUA18_RS12250 (MUA18_12245)	2472021..2473784	-	1764	WP_252549861.1	ABC transporter ATP-binding protein	-
-	2474411..2474471	+	61	-	-	Antitoxin
MUA18_RS12255 (MUA18_12250)	2474488..2474595	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA18_RS12260 (MUA18_12255)	2474729..2475115	-	387	WP_000779353.1	flippase GtxA	-
MUA18_RS12265 (MUA18_12260)	2475383..2476525	+	1143	WP_001176867.1	glycerate kinase	-
MUA18_RS12270 (MUA18_12265)	2476585..2477244	+	660	WP_000831298.1	membrane protein	-
MUA18_RS12275 (MUA18_12270)	2477427..2478638	+	1212	WP_001191927.1	multidrug effflux MFS transporter	-
MUA18_RS12280 (MUA18_12275)	2478761..2479234	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240363 WP_000482647.1 NZ_CP094780:c2474595-2474488 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240363 NZ_LS997868:590882-591169 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240363 NZ_CP094780:2474411-2474471 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin